Greco L, Auricchio S, Mayer M, Grimaldi M
Department of Clinical Pediatrics, 2nd Faculty of Medicine, University of Naples, Italy.
J Pediatr Gastroenterol Nutr. 1988 May-Jun;7(3):395-9. doi: 10.1097/00005176-198805000-00013.
This study explored whether risk or protective nutritional factors have a role in childhood celiac disease. The effect of bottle feeding and early introduction of gluten to the diet was evaluated in a case control study. For each case, about 10 controls were recruited: sample size was determined as required for the evaluation of the study hypothesis. Patients were significantly less breast fed than were controls. Bottle-fed children had an earlier introduction of gluten to the diet than did controls, but when early gluten introduction was analyzed across strata of breast-fed or bottle-fed children, no risk was attributed to it. Bottle feeding appeared to be a significant risk factor in children who received gluten early as well as in those who received gluten later. Breast-feeding rates for patients and controls were equal at birth, but lower for patients by the age of 1 month: from then onward, there was a constant difference between patients and controls regarding the percentage still at breast. Interruption of breast feeding was a risk factor in celiac disease, but early gluten introduction did not appear to be a similar risk factor in the present study.
本研究探讨了风险或保护性营养因素在儿童乳糜泻中是否起作用。在一项病例对照研究中评估了奶瓶喂养和饮食中早期引入麸质的影响。对于每个病例，招募了约10名对照：样本量根据评估研究假设的需要确定。患者母乳喂养的比例明显低于对照。奶瓶喂养的儿童饮食中麸质的引入比对照早，但在按母乳喂养或奶瓶喂养儿童分层分析早期麸质引入时，未发现其具有风险。奶瓶喂养似乎是早期摄入麸质的儿童以及后期摄入麸质的儿童的一个重要风险因素。患者和对照在出生时的母乳喂养率相同，但在1个月大时患者的母乳喂养率较低：从那时起，患者和对照在仍进行母乳喂养的百分比方面一直存在差异。母乳喂养中断是乳糜泻的一个风险因素，但在本研究中早期引入麸质似乎不是类似的风险因素。
