Department of Cardiology, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University School of Medicine, Changsha, Hunan, China.
Biomed Pharmacother. 2021 Jul;139:111555. doi: 10.1016/j.biopha.2021.111555. Epub 2021 Apr 15.
Cardiovascular disease (CVD) is the most deadly disease, which can cause sudden death, in which inflammation is a key factor in its occurrence and development. High-mobility group box 1 (HMGB1) is a novel nuclear DNA-binding protein that activates innate immunity to induce inflammation in CVD. HMGB1 exists in the cytoplasm and nucleus of different cell types, including those in the heart. By binding to its receptors, HMGB1 triggers a variety of signaling cascades, leading to inflammation and CVD. To help develop HMGB1-targeted therapies, here we discuss HMGB1 and its biological functions, receptors, signaling pathways, and pathophysiology related to inflammation and CVD, including cardiac remodeling, cardiac hypertrophy, myocardial infarction, heart failure, pulmonary hypertension, atherosclerosis, and cardiomyopathy.
心血管疾病（CVD）是最致命的疾病，可导致猝死，其中炎症是其发生和发展的关键因素。高迁移率族蛋白 B1（HMGB1）是一种新型的核 DNA 结合蛋白，可激活先天免疫，诱导 CVD 中的炎症。HMGB1 存在于不同细胞类型的细胞质和细胞核中，包括心脏细胞。HMGB1 通过与其受体结合，触发多种信号级联反应，导致炎症和 CVD。为了帮助开发针对 HMGB1 的治疗方法，我们在这里讨论 HMGB1 及其生物学功能、受体、信号通路以及与炎症和 CVD 相关的病理生理学，包括心脏重构、心脏肥大、心肌梗死、心力衰竭、肺动脉高压、动脉粥样硬化和心肌病。
