高迁移率族蛋白 1 在心血管疾病中的作用。
Role of High Mobility Group Box 1 in Cardiovascular Diseases.
机构信息
Department of Physiological Sciences, EVMS, Norfolk, Virginia, 23501, USA.
出版信息
Inflammation. 2022 Oct;45(5):1864-1874. doi: 10.1007/s10753-022-01668-3. Epub 2022 Apr 7.
Abstract
High Mobility Group Box 1 (HMGB1) is a ubiquitous, highly conserved nuclear and cytosolic protein that has diverse biological roles depending on its cellular location and posttranslational modifications. The HMGB1 is localized in the nucleus but can be translocated to the cytoplasm to modulate the intracellular signaling and eventually secreted outside the cells. It is widely established that HMGB1 plays a key role in inflammation; however, the role of HMGB1 in the cardiovascular diseases is not well understood. In this review, we will discuss the latest reports on the pathophysiological link between HMGB1 and cardiovascular complications, with special emphasis on the inflammation. Thus, the understanding of the role of HMGB1 may provide new insights into developing new HMGB1-based therapies.
摘要
高迁移率族蛋白 B1（HMGB1）是一种广泛存在且高度保守的核蛋白和胞浆蛋白，其具有多种生物学功能，取决于其细胞内位置和翻译后修饰。HMGB1 定位于细胞核内，但可转移至细胞质中，以调节细胞内信号转导，最终分泌到细胞外。广泛认为 HMGB1 在炎症中起关键作用；然而，HMGB1 在心血管疾病中的作用尚不清楚。在本综述中，我们将讨论 HMGB1 与心血管并发症之间的病理生理联系的最新报告，特别强调炎症。因此，对 HMGB1 作用的理解可能为开发基于 HMGB1 的新疗法提供新的见解。
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