Berger J R, Mucke L
Department of Neurology, University of Miami School of Medicine, FL 33136.
Neurology. 1988 Jul;38(7):1060-5. doi: 10.1212/wnl.38.7.1060.
Two human immunodeficiency virus seropositive patients with progressive multifocal leukoencephalopathy (PML) exhibited a dramatic though incomplete recovery of neurologic function and have survived for more than 30 months since the onset of symptoms. PML was the initial manifestation of the acquired immune deficiency syndrome (AIDS) in both patients, though other opportunistic infections have subsequently supervened in one. Brain tissue from both patients obtained by stereotactic biopsy showed the typical features of PML, but was also characterized by an unusually prominent inflammatory response. Neurologic improvement did not appear to correlate with clinical or laboratory measurements of immunologic improvement. One patient continued to display neurologic recovery despite the development of other opportunistic infections. Though atypical, PML in AIDS may be associated with prolonged survival.
两名人类免疫缺陷病毒血清阳性且患有进行性多灶性白质脑病（PML）的患者，其神经功能出现了显著但不完全的恢复，自症状出现以来已存活超过30个月。PML是这两名患者获得性免疫缺陷综合征（AIDS）的初始表现，不过其中一名患者随后出现了其他机会性感染。通过立体定向活检获取的两名患者的脑组织均显示出PML的典型特征，但也具有异常突出的炎症反应。神经功能的改善似乎与免疫改善的临床或实验室测量结果无关。尽管出现了其他机会性感染，但一名患者仍持续表现出神经功能的恢复。虽然不典型，但AIDS患者中的PML可能与延长生存期有关。
