Chen Sijin, Huang Shuting, Li Yan, Zhou Chuncai
School of Material Science and Engineering, Tongji University, Shanghai, China.
Front Chem. 2021 Mar 30;9:659304. doi: 10.3389/fchem.2021.659304. eCollection 2021.
With the advantages in biocompatibility, antimicrobial ability, and comparative facile synthesis technology, poly-L-lysine (PLL) has received considerable attention in recent years. Different arrangement forms and structures of the backbone endow lysine-based polymers with versatile applications, especially for ε-poly-L-lysine (EPL) and lysine-based dendrimer (LBD) compounds. This review summarized the advanced development of the synthesis and modification strategies of EPL and LBD, focus on the modification of bio-synthesis and artificial synthesis, respectively. Meanwhile, biomedical fields, where EPL and LBD are mainly utilized, such as agents, adjuvants, or carriers to anti-pathogen or used in tumor or gene therapies, are also introduced. With the deeper of knowledge of pharmacodynamics and pharmacokinetics of the drug system, the design and synthesis of these drugs can be further optimized. Furthermore, the performances of combination with other advanced methodologies and technologies demonstrated that challenges, such as scale production and high expenses, will not hinder the prospective future of lysine-based polymers.
聚-L-赖氨酸（PLL）由于具有生物相容性、抗菌能力以及相对简便的合成技术等优点，近年来受到了广泛关注。主链的不同排列形式和结构赋予了基于赖氨酸的聚合物多种用途，特别是对于ε-聚-L-赖氨酸（EPL）和基于赖氨酸的树枝状聚合物（LBD）化合物。本文综述了EPL和LBD合成与修饰策略的最新进展，分别重点介绍了生物合成和人工合成的修饰方法。同时，还介绍了EPL和LBD主要应用的生物医学领域，如作为抗病原体的药物、佐剂或载体，或用于肿瘤治疗或基因治疗。随着对药物系统药效学和药代动力学认识的深入，这些药物的设计和合成可以进一步优化。此外，与其他先进方法和技术相结合的性能表明，诸如规模生产和高成本等挑战不会阻碍基于赖氨酸的聚合物的未来前景。
