Yesudasu Vasimalla, Pradhan Himansu Shekhar, Pandya Rahul Jasvanthbhai
Department of ECE, National Institute of Technology Warangal, 506004, TS, India.
Department of EE, Indian Institute of Technology Dharwad, Karnataka, 580011, India.
Heliyon. 2021 Mar 8;7(3):e06321. doi: 10.1016/j.heliyon.2021.e06321. eCollection 2021 Mar.
In the recent years, researchers have contributed substantially in the field of Surface Plasmon Resonance (SPR) sensors and its applications. SPR sensors show the salient features, such as label-free detection, real-time monitoring, small sample size, furnish accurate outcomes at low cost, and smooth handling. Moreover, the SPR sensors are also well-known because of its quantitative and qualitative excellent performance in real-time applications, including drug discovery, environment monitoring, food safety, medical diagnosis, clinical diagnosis, biological studies, and biomolecule interactions. This paper exhibits a comprehensive review of SPR based sensors, such as prism-based SPR with the applications (e.g., biomolecule interaction, medical diagnostic, etc.), fiber-based SPR, and waveguide-based SPR. Furthermore, we summarized the modern designs and techniques with their limitations and challenges in detail. The erudition outlined in this paper can be given an exceptional benefit for the researchers and industry people in the field of SPR based sensors.
近年来，研究人员在表面等离子体共振（SPR）传感器及其应用领域做出了重大贡献。SPR传感器具有显著特点，如无标记检测、实时监测、样本量小、低成本提供准确结果以及操作简便。此外，SPR传感器还因其在实时应用中的定量和定性优异性能而闻名，这些应用包括药物发现、环境监测、食品安全、医学诊断、临床诊断、生物学研究以及生物分子相互作用。本文对基于SPR的传感器进行了全面综述，如基于棱镜的SPR及其应用（如生物分子相互作用、医学诊断等）、基于光纤的SPR和基于波导的SPR。此外，我们详细总结了现代设计和技术及其局限性与挑战。本文所述知识可为基于SPR的传感器领域的研究人员和行业人士带来极大益处。
