As scientists worldwide search for answers to the overwhelmingly unknown behind the deadly pandemic, the literature concerning COVID-19 has been growing exponentially. Keeping abreast of the body of literature at such a rapidly advancing pace poses significant challenges not only to active researchers but also to society as a whole. Although numerous data resources have been made openly available, the analytic and synthetic process that is essential in effectively navigating through the vast amount of information with heightened levels of uncertainty remains a significant bottleneck. We introduce a generic method that facilitates the data collection and sense-making process when dealing with a rapidly growing landscape of a research domain such as COVID-19 at multiple levels of granularity. The method integrates the analysis of structural and temporal patterns in scholarly publications with the delineation of thematic concentrations and the types of uncertainties that may offer additional insights into the complexity of the unknown. We demonstrate the application of the method in a study of the COVID-19 literature.