Department of Pathology, The Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, P.R. China.
Diagn Pathol. 2021 Apr 21;16(1):34. doi: 10.1186/s13000-021-01094-3.
Rhinocerebral mucormycosis is a rare and severe form of opportunistic fungal infection that can develop rapidly and cause significant mortality, particularly among diabetic patients suffering from ketoacidosis. Diagnosing rhinocerebral mucormycosis during the early stages of infection is challenging.
We describe a case of rhinocerebral mucormycosis secondary to severe acute pancreatitis in a patient suffering from diabetic ketoacidosis. In this case, the condition was not diagnosed during the optimal treatment window. we therefore provide a thorough overview of related clinical findings and histopathological characteristics, and we discuss potential differential diagnoses.
In summary, we described a case of rhinocerebral mucormycosis secondary to severe acute pancreatitis in a patient suffering from diabetic ketoacidosis, with the optimal treatment window for this condition having been missed. This report suggests that a definitive mucormycosis diagnosis can be made based upon tissue biopsy that reveals the presence of characteristic hyphae. Early diagnosis and treatment are essential in order to improve patient prognosis.
鼻-脑毛霉病是一种罕见且严重的机会性真菌感染,可迅速发展并导致高死亡率,尤其是在患有糖尿病酮症酸中毒的糖尿病患者中。在感染的早期阶段诊断鼻-脑毛霉病具有挑战性。
我们描述了一例继发于糖尿病酮症酸中毒患者严重急性胰腺炎的鼻-脑毛霉病。在这种情况下,该病症在最佳治疗窗口期间未被诊断出来。因此,我们提供了相关临床发现和组织病理学特征的全面概述,并讨论了潜在的鉴别诊断。
总之,我们描述了一例继发于糖尿病酮症酸中毒患者严重急性胰腺炎的鼻-脑毛霉病,该病症的最佳治疗窗口被错过。本报告表明,基于组织活检可以明确诊断毛霉病,活检中存在特征性的菌丝。早期诊断和治疗对于改善患者预后至关重要。