Worley Morgan L, O'Leary Morgan C, Sackett James R, Schlader Zachary J, Willer Barry, Leddy John J, Johnson Blair D
Center for Research and Education in Special Environments, Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, United States.
Human Integrative Physiology Laboratory, Department of Kinesiology, School of Public Health, Indiana University, Bloomington, IN, United States.
Front Neurol. 2021 Apr 9;12:620757. doi: 10.3389/fneur.2021.620757. eCollection 2021.
Concussions have been shown to result in autonomic dysfunction and altered cerebral vascular function. We tested the hypothesis that concussed athletes (CA) would have altered cerebral vascular function during acute decreases and increases in blood pressure compared to healthy controls (HC). Ten CA (age: 20 ± 2 y, 7 females) and 10 HC (age: 21 ± 2 y, 6 females) completed 5 min of lower body negative pressure (LBNP; -40 mmHg) and 5 min of lower body positive pressure (LBPP; 20 mmHg). Protocols were randomized and separated by 10 min. Mean arterial pressure (MAP) and middle cerebral artery blood velocity (MCAv) were continuously recorded. Cerebral vascular resistance (CVR) was calculated as MAP/MCAv. Values are reported as change from baseline to the last minute achieved (LBNP) or 5 min (LBPP). There were no differences in baseline values between groups. During LBNP, there were no differences in the change for MAP (CA: -23 ± 18 vs. HC: -21 ± 17 cm/s; = 0.80) or MCAv (CA: -13 ± 8 vs. HC: -18 ± 9 cm/s; = 0.19). The change in CVR was different between groups (CA: -0.08 ± 0.26 vs. HC: 0.18 ± 0.24 mmHg/cm/s; = 0.04). Total LBNP time was lower for CA (204 ± 92 s) vs. HC (297 ± 64 s; = 0.04). During LBPP, the change in MAP was not different between groups (CA: 13 ± 6 vs. HC: 10 ± 7 mmHg; = 0.32). The change in MCAv (CA: 7 ± 6 vs. HC: -4 ± 13 cm/s; = 0.04) and CVR (CA: -0.06 ± 0.27 vs. HC: 0.38 ± 0.41 mmHg/cm/s; = 0.03) were different between groups. CA exhibited impaired tolerance to LBNP and had a different cerebral vascular response to LBPP compared to HC.
脑震荡已被证明会导致自主神经功能障碍和脑血管功能改变。我们测试了这样一个假设：与健康对照组（HC）相比，脑震荡运动员（CA）在血压急性下降和上升期间脑血管功能会发生改变。10名CA（年龄：20±2岁，7名女性）和10名HC（年龄：21±2岁，6名女性）完成了5分钟的下体负压（LBNP；-40 mmHg）和5分钟的下体正压（LBPP；20 mmHg）。实验方案是随机的，且间隔10分钟。连续记录平均动脉压（MAP）和大脑中动脉血流速度（MCAv）。脑血管阻力（CVR）计算为MAP/MCAv。数值报告为从基线到达到的最后一分钟（LBNP）或5分钟（LBPP）的变化。两组之间的基线值没有差异。在LBNP期间，MAP的变化（CA：-23±18 vs. HC：-21±17 cm/s；P = 0.80）或MCAv的变化（CA：-13±8 vs. HC：-18±9 cm/s；P = 0.19）没有差异。两组之间CVR的变化不同（CA：-0.08±0.26 vs. HC：0.18±0.24 mmHg/cm/s；P = 0.04）。CA的总LBNP时间（204±92秒）低于HC（297±64秒；P = 0.04）。在LBPP期间，两组之间MAP的变化没有差异（CA：13±6 vs. HC：10±7 mmHg；P = 0.32）。两组之间MCAv的变化（CA：7±6 vs. HC：-4±13 cm/s；P = 0.04）和CVR的变化（CA：-0.06±0.27 vs. HC：0.38±0.41 mmHg/cm/s；P = 0.03）不同。与HC相比，CA对LBNP的耐受性受损，对LBPP的脑血管反应也不同。
