Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Key Laboratory of Oilseeds Processing, Ministry of Agriculture and Rural Affairs, 2 Xudong Second Road, Wuhan, Hubei 430062, People's Republic of China.
Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430060, People's Republic of China.
J Agric Food Chem. 2021 Aug 18;69(32):9124-9136. doi: 10.1021/acs.jafc.0c07323. Epub 2021 Apr 26.
In this study, the effect of algal oil rich in docosahexaenoic acid on the mucosal injury with gut microbiota disorders caused by ceftriaxone sodium (CS) was evaluated. The results showed that algal oil treatment (500 mg kg day) significantly reduced the levels of pro-inflammatory cytokines, including interleukin 6 , interleukin 1β, and tumor necrosis factor α, in the colon. Algal oil restored the CS-induced gut microbiota dysbiosis by elevating some short-chain-fatty-acid-producing bacteria, e.g., and . The CS-induced metabolic disorder was also regulated by algal oil, which was characterized by the modulations of tryptophan metabolism, phospholipid metabolism, and bile acid metabolism. Our results suggested that supplementation of algal oil could alleviate inflammation and promote mucosal healing, which could be a functional food ingredient to protect aganist antibiotic-induced alteration of gut microbiota and metabolic dysbiosis.
在这项研究中，评估了富含二十二碳六烯酸的藻类油对头孢曲松钠（CS）引起的粘膜损伤和肠道微生物群紊乱的影响。结果表明，藻类油处理（500mgkg 天）显著降低了结肠中促炎细胞因子（包括白细胞介素 6、白细胞介素 1β 和肿瘤坏死因子 α）的水平。藻类油通过提高一些产生短链脂肪酸的细菌，如 和 ，来恢复 CS 诱导的肠道微生物群失调。CS 引起的代谢紊乱也被藻类油调节，其特征是色氨酸代谢、磷脂代谢和胆汁酸代谢的调节。我们的结果表明，补充藻类油可以减轻炎症并促进粘膜愈合，这可能是一种功能性食品成分，可防止抗生素引起的肠道微生物群和代谢失调。
