College of Pharmaceutical Sciences, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding, 071002, People's Republic of China.
Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, People's Republic of China.
Appl Microbiol Biotechnol. 2022 May;106(9-10):3337-3350. doi: 10.1007/s00253-022-11939-6. Epub 2022 Apr 29.
Aquatic pathogens, including Vibrio, Edwardsiella, Pseudomonas, and Aeromonas, which could result in bacterial diseases to aquaculture, have seriously threatened the world aquaculture production. Marine-derived fungi, which could produce novel secondary metabolites with significant antibacterial activity, may be an important source for finding effective agents against aquatic pathogens. In this review, a systematically overview of the harm of several aquatic pathogens, and 134 antibacterial secondary metabolites against aquatic pathogens from 13 genera of marine-derived fungi, were summarized and concluded. The aim of this review is to find out the relationships between activity and structural type, between bioactive compounds and their hosts, and so on. Altogether, 95 references published during 1997-2021 were cited. KEY POINTS: •Aquatic pathogens, which could result in bacterial diseases to aquaculture, were described. •Marine fungal metabolites with activities against aquatic pathogens were summarized. •The distributions of these bioactive marine fungal metabolites were analyzed.
水生病原体，包括弧菌、爱德华氏菌、假单胞菌和气单胞菌等，可导致水产养殖中的细菌性疾病，严重威胁着世界水产养殖业的生产。海洋来源的真菌可产生具有显著抗菌活性的新型次级代谢产物，可能是寻找有效抗水生病原体药物的重要来源。在本综述中，对几种水生病原体的危害以及 13 属海洋来源真菌产生的 134 种抗水生病原体的抗菌次级代谢产物进行了系统概述和总结。本综述的目的是找出活性与结构类型之间、生物活性化合物与其宿主之间的关系等。总共引用了 1997 年至 2021 年期间发表的 95 篇参考文献。 关键点： • 描述了可导致水产养殖中细菌性疾病的水生病原体。 • 总结了具有抗水生病原体活性的海洋真菌代谢产物。 • 分析了这些生物活性海洋真菌代谢产物的分布。
