Tomas Ana, Pavlović Nebojša, Stilinović Nebojša, Horvat Olga, Paut-Kusturica Milica, Dugandžija Tihomir, Tomić Zdenko, Sabo Ana
Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
Antibiotics (Basel). 2021 Apr 7;10(4):397. doi: 10.3390/antibiotics10040397.
The aim of this study was to determine and describe trends in antibiotics utilization in Serbia over a ten-year period. Data were retrieved from publicly available annual reports (2010-2019). The results were expressed as Defined Daily Dose (DDD) per 1000 inhabitants per day (DID). All calculations were performed using the DDD values for the 2020 Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) version for each year of the study, to account for the DDD changes during the study period. Antibiotics were classified using the WHO Access, Watch, Reserve (AWaRe) classification. Total utilization of antibacterials for systemic use increased from 17.25 DID in 2010 to 28.65 DID in 2019. A statistically significant increasing trend in the use of the Watch category antibiotics was observed. A tendency towards use of broad-spectrum antibiotics, apparent by a statistically significant increase in the rate of utilization of broad-spectrum macrolides, quinolones and third-generation cephalosporins vs. narrow-spectrum ones, as well as a significant increasing trend in the use of quinolones was identified. Total antibiotic utilization was found to be well above the European average. Several specific problem areas were identified, which requires further efforts to improve antibiotic prescribing. The present study provides the information needed to facilitate antibiotic stewardship in Serbia further and proposes specific interventions to optimize antibiotic use in Serbia.
本研究的目的是确定并描述塞尔维亚十年间抗生素使用情况的趋势。数据取自公开的年度报告（2010 - 2019年）。结果以每千居民每天的限定日剂量（DDD）表示（DID）。所有计算均使用研究各年份的2020年解剖治疗化学/限定日剂量（ATC/DDD）版本的DDD值，以考虑研究期间DDD的变化。抗生素采用世界卫生组织的准入、观察、储备（AWaRe）分类法进行分类。全身用抗菌药物的总使用量从2010年的17.25 DID增加到2019年的28.65 DID。观察到观察类抗生素的使用呈统计学显著增加趋势。发现了使用广谱抗生素的倾向，表现为广谱大环内酯类、喹诺酮类和第三代头孢菌素的使用率相对于窄谱抗生素有统计学显著增加，以及喹诺酮类的使用呈显著增加趋势。发现抗生素总使用量远高于欧洲平均水平。确定了几个特定的问题领域，需要进一步努力改善抗生素处方。本研究提供了进一步促进塞尔维亚抗生素管理所需的信息，并提出了优化塞尔维亚抗生素使用的具体干预措施。
