Zhang Xiangzhi, Xu Xiawei, Wang Jing, Wang Chengbo, Yan Yuying, Wu Aiguo, Ren Yong
Research Group for Fluids and Thermal Engineering, University of Nottingham Ningbo China, Ningbo 315100, China.
Department of Mechanical, Materials and Manufacturing Engineering, University of Nottingham Ningbo China, Ningbo 315100, China.
Micromachines (Basel). 2021 Apr 2;12(4):391. doi: 10.3390/mi12040391.
Separation and detection are ubiquitous in our daily life and they are two of the most important steps toward practical biomedical diagnostics and industrial applications. A deep understanding of working principles and examples of separation and detection enables a plethora of applications from blood test and air/water quality monitoring to food safety and biosecurity; none of which are irrelevant to public health. Microfluidics can separate and detect various particles/aerosols as well as cells/viruses in a cost-effective and easy-to-operate manner. There are a number of papers reviewing microfluidic separation and detection, but to the best of our knowledge, the two topics are normally reviewed separately. In fact, these two themes are closely related with each other from the perspectives of public health: understanding separation or sorting technique will lead to the development of new detection methods, thereby providing new paths to guide the separation routes. Therefore, the purpose of this review paper is two-fold: reporting the latest developments in the application of microfluidics for separation and outlining the emerging research in microfluidic detection. The dominating microfluidics-based passive separation methods and detection methods are discussed, along with the future perspectives and challenges being discussed. Our work inspires novel development of separation and detection methods for the benefits of public health.
分离和检测在我们的日常生活中无处不在，它们是迈向实际生物医学诊断和工业应用的两个最重要步骤。深入了解分离和检测的工作原理及实例，能够实现从血液检测、空气/水质监测到食品安全和生物安全等众多应用；所有这些都与公共卫生息息相关。微流控技术能够以经济高效且易于操作的方式分离和检测各种颗粒/气溶胶以及细胞/病毒。有许多论文对微流控分离和检测进行了综述，但据我们所知，这两个主题通常是分别进行综述的。事实上，从公共卫生的角度来看，这两个主题彼此密切相关：了解分离或分选技术将推动新检测方法的发展，从而为指导分离路线提供新途径。因此，本综述论文的目的有两个：报告微流控技术在分离应用方面的最新进展，并概述微流控检测方面的新兴研究。文中讨论了基于微流控的主要被动分离方法和检测方法，以及未来的前景和挑战。我们的工作激发了分离和检测方法的新发展，以造福公共卫生。
