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牛血清白蛋白-银纳米颗粒：一种用于皮肤癌传统治疗和光热治疗的潜在多模态疗法。

BSA-Silver Nanoparticles: A Potential Multimodal Therapeutics for Conventional and Photothermal Treatment of Skin Cancer.

作者信息

Kim Dasom, Amatya Reeju, Hwang Seungmi, Lee Sumi, Min Kyoung Ah, Shin Meong Cheol

机构信息

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, 501 Jinju Daero, Jinju, Gyeongnam 52828, Korea.

College of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, 197 Injero, Gimhae, Gyeongnam 50834, Korea.

出版信息

Pharmaceutics. 2021 Apr 17;13(4):575. doi: 10.3390/pharmaceutics13040575.

DOI:10.3390/pharmaceutics13040575
PMID:33920666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8073043/
Abstract

Silver nanoparticles (NPs) have attracted a considerable interest in the field of cancer research due to their potential utility in cancer therapy. In the present study, we developed bovine serum albumin (BSA)-coated silver NPs (BSA-Silver NPs) and characterized in vitro multimodal therapeutic activities of NPs for the treatment of skin cancer. BSA-Silver NPs were synthesized by a single-step reduction process, and the successful preparation was verified through a list of physical characterizations, including transmission electron microscopy (TEM), ultraviolet-visible (UV-VIS) light spectroscopy, dynamic light scattering (DLS), and Fourier transform infrared (FT-IR) spectroscopy. The synthesized BSA-Silver NPs showed marked cytocidal effects on B16F10 melanoma cells, which was likely caused by oxidative stress. BSA-Silver NPs also elicited significant anti-angiogenic effects on HUVEC (human umbilical vein endothelial cell) by inhibiting their proliferation, migration, and tube formation. Moreover, BSA-Silver NPs showed a considerable light-to-heat conversion ability, suggesting their utility as photothermal agents. Overall, our findings suggest that BSA-Silver NPs may be promising candidates for the multimodal therapy of skin cancer.

摘要

由于银纳米颗粒（NPs）在癌症治疗中的潜在用途，它们在癌症研究领域引起了相当大的关注。在本研究中，我们开发了牛血清白蛋白（BSA）包覆的银纳米颗粒（BSA-银纳米颗粒），并对纳米颗粒治疗皮肤癌的体外多模态治疗活性进行了表征。BSA-银纳米颗粒通过一步还原法合成，并通过一系列物理表征进行了成功制备的验证，包括透射电子显微镜（TEM）、紫外可见（UV-VIS）光谱、动态光散射（DLS）和傅里叶变换红外（FT-IR）光谱。合成的BSA-银纳米颗粒对B16F10黑色素瘤细胞显示出显著的杀细胞作用，这可能是由氧化应激引起的。BSA-银纳米颗粒还通过抑制人脐静脉内皮细胞（HUVEC）的增殖、迁移和管形成，对其产生显著的抗血管生成作用。此外，BSA-银纳米颗粒表现出相当大的光热转换能力，表明它们可作为光热剂。总体而言，我们的研究结果表明，BSA-银纳米颗粒可能是皮肤癌多模态治疗的有前途的候选者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/8843baff06da/pharmaceutics-13-00575-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/a91b1fe737c2/pharmaceutics-13-00575-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/ce4cb1bdc53f/pharmaceutics-13-00575-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/27df04328fc0/pharmaceutics-13-00575-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/591acfcdf481/pharmaceutics-13-00575-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/58f467bbcfb9/pharmaceutics-13-00575-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/4478853f8c2e/pharmaceutics-13-00575-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/8843baff06da/pharmaceutics-13-00575-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/a91b1fe737c2/pharmaceutics-13-00575-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/ce4cb1bdc53f/pharmaceutics-13-00575-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/27df04328fc0/pharmaceutics-13-00575-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/591acfcdf481/pharmaceutics-13-00575-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/58f467bbcfb9/pharmaceutics-13-00575-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/4478853f8c2e/pharmaceutics-13-00575-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/312f/8073043/8843baff06da/pharmaceutics-13-00575-g007.jpg

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