Wilk Sebastian, Benko Aleksandra
Faculty of Materials Science and Ceramics, AGH University of Science and Technology, A. Mickiewicz 30 Avenue, 30-059 Krakow, Poland.
J Funct Biomater. 2021 Apr 16;12(2):26. doi: 10.3390/jfb12020026.
Biopolymers formed into a fibrous morphology through electrospinning are of increasing interest in the field of biomedicine due to their intrinsic biocompatibility and biodegradability and their ability to be biomimetic to various fibrous structures present in animal tissues. However, their mechanical properties are often unsatisfactory and their processing may be troublesome. Thus, extensive research interest is focused on improving these qualities. This review article presents the selection of the recent advances in techniques aimed to improve the electrospinnability of various biopolymers (polysaccharides, polynucleotides, peptides, and phospholipids). The electrospinning of single materials, and the variety of co-polymers, with and without additives, is covered. Additionally, various crosslinking strategies are presented. Examples of cytocompatibility, biocompatibility, and antimicrobial properties are analyzed. Special attention is given to whey protein isolate as an example of a novel, promising, green material with good potential in the field of biomedicine. This review ends with a brief summary and outlook for the biomedical applicability of electrospinnable biopolymers.
通过静电纺丝形成纤维形态的生物聚合物，因其固有的生物相容性和生物降解性以及能够模拟动物组织中存在的各种纤维结构的能力，在生物医学领域越来越受到关注。然而，它们的机械性能往往不尽人意，且加工过程可能很麻烦。因此，广泛的研究兴趣集中在改善这些性质上。这篇综述文章介绍了旨在提高各种生物聚合物（多糖、多核苷酸、肽和磷脂）可静电纺丝性的技术的最新进展。涵盖了单一材料以及有或无添加剂的各种共聚物的静电纺丝。此外，还介绍了各种交联策略。分析了细胞相容性、生物相容性和抗菌性能的实例。特别关注乳清分离蛋白，它是一种新型、有前景的绿色材料，在生物医学领域具有良好的潜力。这篇综述最后对可静电纺丝生物聚合物在生物医学中的适用性进行了简要总结和展望。
