Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, via S. Pansini 5, 80131 Napoli, Italy.
CEINGE-Biotecnologie Avanzate, via G. Salvatore 486, 80145 Napoli, Italy.
Genes (Basel). 2021 Apr 27;12(5):654. doi: 10.3390/genes12050654.
Fifteen percent of male infertility is associated with urogenital infections; several pathogens are able to alter the testicular and accessory glands' microenvironment, resulting in the impairment of biofunctional sperm parameters. The purpose of this study was to assess the influence of urogenital infections on the quality of 53 human semen samples through standard analysis, microbiological evaluation, and molecular characterization of sperm DNA damage. The results showed a significant correlation between infected status and semen volume, sperm concentration, and motility. Moreover, a high risk of fragmented sperm DNA was demonstrated in the altered semen samples. Urogenital infections are often asymptomatic and thus an in-depth evaluation of the seminal sample can allow for both the diagnosis and therapy of infections while providing more indicators for male infertility management.
15%的男性不育与泌尿生殖系统感染有关；一些病原体能够改变睾丸和附属腺体的微环境，导致生物功能精子参数受损。本研究旨在通过标准分析、微生物评估和精子 DNA 损伤的分子特征评估泌尿生殖系统感染对 53 个人类精液样本质量的影响。结果表明，感染状态与精液量、精子浓度和活力之间存在显著相关性。此外，在改变的精液样本中显示出精子 DNA 碎片化的高风险。泌尿生殖系统感染通常无症状，因此对精液样本进行深入评估不仅可以诊断和治疗感染，还可以为男性不育管理提供更多指标。
