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健康的肠道功能依赖于协调的肠神经系统、免疫系统和上皮细胞反应。

Healthy Intestinal Function Relies on Coordinated Enteric Nervous System, Immune System, and Epithelium Responses.

机构信息

Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston TX USA.

Immunology Program of the Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY USA.

出版信息

Gut Microbes. 2021 Jan-Dec;13(1):1-14. doi: 10.1080/19490976.2021.1916376.

DOI:10.1080/19490976.2021.1916376
PMID:33929291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8096330/
Abstract

During both health and disease, a coordinated response between the epithelium, immune system, and enteric nervous system is required for proper intestinal function. While each system responds to a number of common stimuli, their coordinated responses support digestion as well as responses and recovery following injury or pathogenic infections. In this review, we discuss how individual responses to common signals work together to support these critical functions.

摘要

在健康和疾病期间，上皮细胞、免疫系统和肠神经系统之间需要协调反应，以维持肠道的正常功能。虽然每个系统都会对许多常见刺激做出反应，但它们的协调反应不仅支持消化，还支持损伤或病原感染后的反应和恢复。在这篇综述中，我们讨论了个体对常见信号的反应如何协同作用，以支持这些关键功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c30/8096330/b695d67ae0ee/KGMI_A_1916376_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c30/8096330/b1b93a1f3838/KGMI_A_1916376_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c30/8096330/b695d67ae0ee/KGMI_A_1916376_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c30/8096330/b1b93a1f3838/KGMI_A_1916376_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c30/8096330/b695d67ae0ee/KGMI_A_1916376_F0002_OC.jpg

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2
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Nature. 2021 Feb;590(7844):151-156. doi: 10.1038/s41586-020-03118-2. Epub 2021 Jan 13.
3
Intestinal Microbes in Autoimmune and Inflammatory Disease.肠道微生物与自身免疫和炎症性疾病
墨西哥丽脂鲤（Astyanax mexicanus）表层鱼和洞穴鱼的肠神经嵴发育
Differentiation. 2025 Jun 13;144:100881. doi: 10.1016/j.diff.2025.100881.
4
Bacteroides, Metabolites, and Lymphocytes: A Triad of Biomarkers in Small Intestinal Bacterial Overgrowth.拟杆菌、代谢产物与淋巴细胞：小肠细菌过度生长中的三联生物标志物
Food Sci Nutr. 2025 Jun 20;13(6):e70367. doi: 10.1002/fsn3.70367. eCollection 2025 Jun.
5
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