Xavier Thaís Aparecida, Madalena Isabela Ribeiro, da Silva Raquel Assed Bezerra, da Silva Léa Assed Bezerra, Silva Marcelo José Barbosa, De Rossi Andiara, Küchler Erika Calvano, Fukada Sandra Yasuyo
Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - Avenida do Café, São Paulo, Brazil.
Acta Odontol Scand. 2021 Nov;79(8):600-605. doi: 10.1080/00016357.2021.1918762. Epub 2021 May 4.
To verify the association between 25(OH)D level and polymorphisms in the vitamin D receptor gene () with the disturbance in the dental development and eruption.
A total of 183 children from two datasets were evaluated. The first dataset was a case-control (15:15) designed to assess if persistent primary tooth (PPT) is associate with serum 25(OH)D level and with genetic polymorphisms in . The second dataset of genomic DNA samples from 54 children with delayed tooth eruption (DTE) and 99 controls were analysed to verify if genetic polymorphisms in (rs2228570 and rs739837) are associated with DTE. The 25(OH)D and the genotyping/allele distribution were analysed using the -test and chi-square test, respectively.
The level of 25(OH)D in the PPT group (24.9 ± 6.4 mg/mL) was significantly lower than the control (30.0 ± 7.0 mg/mL) (=.047). Our data show that children with 25(OH)D deficiency are more likely to present PPT (OR = 2.36; 95%CI: 1.51, 3.70). The rs739837 and rs2228570 polymorphisms were not associated with DTE (OR = 1.44; 95%CI: 0.87, 2.39 and OR = 0.80; 95%CI: 0.45, 1.44, respectively).
Vitamin D deficiency is a risk factor for PPT.
验证25(OH)D水平及维生素D受体基因（）多态性与牙齿发育和萌出障碍之间的关联。
对来自两个数据集的183名儿童进行评估。第一个数据集是病例对照研究（15:15），旨在评估乳牙滞留（PPT）是否与血清25(OH)D水平及基因多态性相关。分析了来自54名牙齿萌出延迟（DTE）儿童和99名对照的基因组DNA样本的第二个数据集，以验证基因（rs2228570和rs739837）多态性是否与DTE相关。分别使用检验和卡方检验分析25(OH)D水平及基因分型/等位基因分布。
PPT组的25(OH)D水平（24.9±6.4mg/mL）显著低于对照组（30.0±7.0mg/mL）（=0.047）。我们的数据表明，25(OH)D缺乏的儿童更有可能出现PPT（OR=2.36；95%CI：1.51，3.70）。rs739837和rs2228570多态性与DTE无关（OR分别为1.44；95%CI：0.87，2.39和OR=0.80；95%CI：0.45，1.44）。
维生素D缺乏是乳牙滞留的一个危险因素。
