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塞拉利昂母婴医疗延误对新生儿死亡率的影响:在儿童健康和死亡率监测预防(CHAMPS)站点的社会尸检病例对照研究。

Effect of Delays in Maternal Access to Healthcare on Neonatal Mortality in Sierra Leone: A Social Autopsy Case-Control Study at a Child Health and Mortality Prevention Surveillance (CHAMPS) Site.

机构信息

Emory University School of Public Health, Atlanta, GA, USA.

Centers for Disease Control and Prevention, Atlanta, GA, USA.

出版信息

Matern Child Health J. 2021 Aug;25(8):1326-1335. doi: 10.1007/s10995-021-03132-4. Epub 2021 May 4.

DOI:10.1007/s10995-021-03132-4
PMID:33945079
Abstract

INTRODUCTION

In low-resource settings, a social autopsy tool has been proposed to measure the effect of delays in access to healthcare on deaths, complementing verbal autopsy questionnaires routinely used to determine cause of death. This study estimates the contribution of various delays in maternal healthcare to subsequent neonatal mortality using a social autopsy case-control design.

METHODS

This study was conducted at the Child Health and Mortality Prevention Surveillance (CHAMPS) Sierra Leone site (Makeni City and surrounding rural areas). Cases were neonatal deaths in the catchment area, and controls were sex- and area-matched living neonates. Odds ratios for maternal barriers to care and neonatal death were estimated, and stratified models examined this association by neonatal age and medical complications.

RESULTS

Of 53 neonatal deaths, 26.4% of mothers experienced at least one delay during pregnancy or delivery compared to 46.9% of mothers of stillbirths and 18.6% of control mothers. The most commonly reported delay among neonatal deaths was receiving care at the facility (18.9%). Experiencing any barrier was weakly associated (OR 1.68, CI 0.77, 3.67) and a delay in receiving care at the facility was strongly associated (OR 19.15, CI 3.90, 94.19) with neonatal death.

DISCUSSION

Delays in healthcare are associated with neonatal death, particularly delays experienced at the healthcare facility. Heterogeneity exists in the prevalence of specific delays, which has implications for local public health policy. The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

摘要

简介

在资源匮乏的环境下,有一种社会解剖工具被提出来用以评估获得医疗服务的延迟对死亡的影响,作为一种补充手段,该工具与常规使用的死因推断调查问卷相结合来判断死亡原因。本研究采用社会解剖病例对照设计,旨在评估母婴医疗保健各个环节的延迟对随后新生儿死亡的影响。

方法

本研究在塞拉利昂儿童健康和死亡率监测(CHAMPS)项目的一个监测点(马克尼市及周边农村地区)进行。病例为监测区域内的新生儿死亡,对照为性别和地区匹配的存活新生儿。我们对母婴医疗障碍与新生儿死亡的比值比进行了估计,并通过新生儿年龄和医疗并发症进行了分层模型分析。

结果

在 53 例新生儿死亡中,26.4%的母亲在妊娠或分娩期间至少经历了一次延迟,而死产和对照组母亲的这一比例分别为 46.9%和 18.6%。在新生儿死亡中,最常报告的延迟是在医疗机构接受治疗(18.9%)。经历任何障碍与新生儿死亡的关联较弱(比值比 1.68,95%置信区间 0.77,3.67),而在医疗机构接受治疗的延迟与新生儿死亡的关联较强(比值比 19.15,95%置信区间 3.90,94.19)。

讨论

医疗保健的延迟与新生儿死亡有关,特别是在医疗机构中经历的延迟。具体延迟的发生率存在差异,这对当地公共卫生政策有一定影响。本报告中的发现和结论仅代表作者的观点,不一定代表疾病预防控制中心的官方立场。

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Unconditional or Conditional Logistic Regression Model for Age-Matched Case-Control Data?年龄匹配的病例对照数据应采用无条件还是条件逻辑回归模型?
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