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美国和欧洲通过法定授权实施的新冠疫情社交距离干预措施及其与死亡率的观察性关联

Covid-19 Social Distancing Interventions by Statutory Mandate and Their Observational Correlation to Mortality in the United States and Europe.

作者信息

Mccafferty Sean, Ashley Sean

机构信息

Department of Ophthalmology, College of Medicine, University of Arizona, Tucson, AZ, USA.

College of Optical Sciences, University of Arizona, Tucson, AZ, USA.

出版信息

Pragmat Obs Res. 2021 Apr 27;12:15-24. doi: 10.2147/POR.S298309. eCollection 2021.

DOI:10.2147/POR.S298309
PMID:33948094
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8088306/
Abstract

PURPOSE

Evaluate the correlation between statutory social distancing interventions and Covid-19 mortality independently in both the United States and Europe. The study is presented as a potential methodology to evaluate the effectiveness of statutory social distancing policy.

PATIENTS AND METHODS

Twenty-seven states in the United States and, separately, 12 European countries were selected which had clearly defined and dated establishment of statewide or national mandates for social distancing measures from the Institute for Health Metrics and Evaluation (IHME) data. Mandated social distancing measures considered in this study include: School closures, Prohibition on mass gatherings, business closures, stay at home orders, severe travel restrictions, and closure of non-essential businesses. The state/country Covid-19 peak mortality rate (PMR) was defined as the initial averaged normalized maximum during which social distancing mandates were in effect. Mandate-days were defined as the total days legislative mandates were in place to the PMR.

RESULTS

The normalized peak mortality rate in the US and in Europe did not demonstrate a statistically significant correlation to the total mandate days (R-squared=0.053, p=0.246, R-squared=2.4E-06, p=0.996). A significant correlation was found between normalized mortality rate and state/country population density (R-squared=0.524, p=0.00002,R-squared=0.397, p=0.0281).

DISCUSSION

The analysis appears to suggest no mandate effective reduction in Covid-19 mortality rate to its defined initial peak when interpreting their mean-effect. A strong correlation to population density suggests human interaction frequency does affect the peak mortality rate.

摘要

目的

分别评估美国和欧洲法定社交距离干预措施与新冠病毒死亡率之间的相关性。本研究作为一种潜在方法,用于评估法定社交距离政策的有效性。

患者与方法

从美国27个州以及另外12个欧洲国家中进行选择,这些地区依据健康指标与评估研究所(IHME)的数据,明确界定并记录了全州或全国范围内社交距离措施的实施时间。本研究中考虑的法定社交距离措施包括:学校关闭、禁止大规模集会、企业关闭、居家令、严格的旅行限制以及非必要业务关闭。州/国家的新冠病毒峰值死亡率(PMR)定义为社交距离措施生效期间最初的平均标准化最大值。强制天数定义为从立法强制令生效到达到PMR的总天数。

结果

美国和欧洲的标准化峰值死亡率与总强制天数之间未显示出统计学上的显著相关性(R平方 = 0.053,p = 0.246;R平方 = 2.4E - 06,p = 0.996)。标准化死亡率与州/国家人口密度之间存在显著相关性(R平方 = 0.524,p = 0.00002;R平方 = 0.397,p = 0.0

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2216/8088306/fb3288ee88a4/POR-12-15-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2216/8088306/689909f4fba3/POR-12-15-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2216/8088306/576e74729db2/POR-12-15-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2216/8088306/7c36761382d6/POR-12-15-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2216/8088306/fb3288ee88a4/POR-12-15-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2216/8088306/689909f4fba3/POR-12-15-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2216/8088306/576e74729db2/POR-12-15-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2216/8088306/7c36761382d6/POR-12-15-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2216/8088306/fb3288ee88a4/POR-12-15-g0004.jpg

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