血液恶性肿瘤患儿的 EQ-5D-Y-3L 和 EQ-5D-Y-5L 的患者-照顾者一致性和重测信度。
Patient-caregiver agreement and test-retest reliability of the EQ-5D-Y-3L and EQ-5D-Y-5L in paediatric patients with haematological malignancies.
机构信息
Department of Paediatrics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Medical Psychology and Psychotherapy, Erasmus University, Rotterdam, The Netherlands.
出版信息
Eur J Health Econ. 2021 Sep;22(7):1103-1113. doi: 10.1007/s10198-021-01309-w. Epub 2021 May 5.
BACKGROUND
In 2019, the EuroQol Group developed a 'beta' 5-level version of EQ-5D-Y (Y-5L) by increasing the number of descriptive levels to five for each health dimension, as compared to the standard 3-level EQ-5D-Y (Y-3L).
OBJECTIVE
To assess patient-caregiver agreement and test-retest reliability of the Y-5L and Y-3L in paediatric patients with haematological malignancies.
METHODS
Paediatric inpatients aged 8-17 years were interviewed with the Y-5L and Y-3L questionnaires twice, while their caregivers were interviewed at the same time using the proxy versions of the questionnaires. Patient-caregiver agreement and test-retest reliability were assessed using Gwet's agreement coefficient (Gwet's AC1) for EQ-5D dimensions and the intraclass correlation coefficient (ICC) for the EQ VAS.
RESULTS
Ninety-six patient-caregiver dyads participated in the study. Patient-caregiver agreement on the EQ-5D-Y descriptive system was moderate to good for both the Y-3L and Y-5L, but poor on the EQ VAS. Test-retest reliability of the descriptive system was good to very good for the Y-3L and moderate to good for the Y-5L in children, and fair to good for both versions of EQ-5D-Y in proxies. The EQ VAS showed good test-retest reliability in both children and caregivers. In a subgroup analysis of results in younger patients aged 8-10 years, patient-caregiver agreement and test-retest reliability were also observed to range from moderate to very good.
CONCLUSION
Both the Y-3L and Y-5L descriptive systems showed acceptable patient-caregiver agreement and test-retest reliability when used to assess the HRQoL of children and adolescents with haematological malignancies, including in younger patients.
背景
2019 年，欧洲质量生活组通过将每个健康维度的描述水平从标准的 EQ-5D-Y（Y-3L）的 3 级增加到 5 级，开发了 EQ-5D-Y（Y-5L）的“β”5 级版本。
目的
评估 Y-5L 和 Y-3L 在血液恶性肿瘤儿科患者中的患者-照顾者一致性和测试-重测信度。
方法
8-17 岁的儿科住院患者两次接受 Y-5L 和 Y-3L 问卷访谈，同时使用问卷的代理版本对其照顾者进行访谈。使用 EQ-5D 维度的 Gwet 一致性系数（Gwet's AC1）和 EQ VAS 的组内相关系数（ICC）评估患者-照顾者一致性和测试-重测信度。
结果
96 对患者-照顾者参与了研究。对于 Y-3L 和 Y-5L，患者-照顾者在 EQ-5D-Y 描述系统上的一致性为中等至良好，但在 EQ VAS 上则较差。对于儿童，Y-3L 的描述系统的测试-重测信度为良好至非常好，而 Y-5L 的测试-重测信度为中等至良好，对于两个版本的 EQ-5D-Y，代理的测试-重测信度为良好至良好。EQ VAS 在儿童和照顾者中均表现出良好的测试-重测信度。在年龄较小的 8-10 岁患者的亚组分析中，也观察到患者-照顾者的一致性和测试-重测信度在中等至非常好的范围内。
结论
在评估血液恶性肿瘤儿童和青少年的 HRQoL 时，Y-3L 和 Y-5L 描述系统均表现出可接受的患者-照顾者一致性和测试-重测信度，包括在年龄较小的患者中。
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