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癌症研究中使用组织样本进行生物标志物研究时的质量考量

Quality Considerations When Using Tissue Samples for Biomarker Studies in Cancer Research.

作者信息

Speirs Valerie

机构信息

Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, Scotland, UK.

出版信息

Biomark Insights. 2021 Apr 20;16:11772719211009513. doi: 10.1177/11772719211009513. eCollection 2021.

DOI:10.1177/11772719211009513
PMID:33958852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8060748/
Abstract

Tissue obtained from biobanks is frequently employed in biomarker studies. Biomarkers define objective, measurable characteristics of biological and biomedical procedures and have been used as indicators of clinical outcome. This article outlines some of the steps scientists should consider when embarking on biomarker research in cancer research using samples from biobanks and the importance and challenges of linking clinical data to biological samples.

摘要

从生物样本库获取的组织经常用于生物标志物研究。生物标志物定义了生物和生物医学程序的客观、可测量特征，并已被用作临床结果的指标。本文概述了科学家在利用生物样本库的样本开展癌症研究中的生物标志物研究时应考虑的一些步骤，以及将临床数据与生物样本相联系的重要性和挑战。