al-Hadramy M S, Zawawi T H, Abdelwahab S M
Department of Medicine, Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Eur J Clin Nutr. 1988 Apr;42(4):359-62.
During the month of Muslim fasting (Ramadan) many people alter their sleeping habits and stay awake most of the night. We investigated the effect of this alteration on morning and midnight cortisol levels in 10 healthy adults in their homes. Four of the subjects showed alteration of the cortisol rhythm during the last 2 weeks of fasting with reversal of the morning/midnight ratio in some values. One lady was admitted for 24-h cortisol profile on Day 15 of Ramadan when the acrophase and nadir showed a forward shift by about 5-6 h, consistent with the shift of the subject's sleep. The morning cortisol returned to normal in all subjects 4 weeks after Ramadan. However, the midnight value was above 250 nmol/l in three of the subjects who exhibited the alteration during Ramadan. These findings suggest that single-point cortisol values can be misleading in many Muslin countries during or shortly after Ramadan.
在穆斯林斋月期间，许多人会改变睡眠习惯，夜间大部分时间保持清醒。我们对10名居家健康成年人进行了研究，以调查这种改变对其上午和午夜皮质醇水平的影响。在斋月的最后两周，4名受试者的皮质醇节律发生改变，部分数值的上午/午夜比值出现逆转。一名女性在斋月第15天接受了24小时皮质醇监测，其时相峰点和最低点向前移了约5 - 6小时，这与该受试者睡眠的改变一致。斋月结束4周后，所有受试者上午的皮质醇水平恢复正常。然而，在斋月期间出现节律改变的3名受试者中，午夜皮质醇值高于250 nmol/l。这些发现表明，在斋月期间或斋月刚结束后，在许多穆斯林国家，单点皮质醇值可能会产生误导。
