Molecular Physiology of Bone, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Molecular Physiology of Bone, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Best Pract Res Clin Endocrinol Metab. 2021 Jul;35(4):101545. doi: 10.1016/j.beem.2021.101545. Epub 2021 May 1.
Bone marrow adipose tissue (BMAT) has been considered for several decades as a silent bystander that fills empty space left in bone marrow following age-related decrease in hematopoiesis. However, recently new discoveries revealed BMAT as a secretory and metabolically active organ contributing to bone and whole-body energy metabolism. BMAT exhibits metabolic functions distinct from extramedullary adipose depots, relevant to its role in regulation of energy metabolism and its contribution to fracture risk observed in metabolic bone diseases. This review discusses novel insights of BMAT with particular emphasis on its contribution to the regulation of bone homeostasis. We also discuss the role of BMAT in regulation of fuel utilization and energy use that affect skeletal stem cell functions.
骨髓脂肪组织（BMAT）几十年来一直被认为是一种沉默的旁观者，它填补了造血功能随着年龄增长而减少后骨髓中留下的空白。然而，最近的新发现揭示了 BMAT 作为一个分泌和代谢活跃的器官，有助于骨骼和全身能量代谢。BMAT 表现出与骨髓外脂肪组织不同的代谢功能，这与其在调节能量代谢中的作用以及在代谢性骨病中观察到的骨折风险有关。本综述讨论了 BMAT 的新见解，特别强调了它对骨稳态调节的贡献。我们还讨论了 BMAT 在调节燃料利用和能量利用中的作用，这些作用会影响骨骼干细胞的功能。
