单核转录组分析揭示糖尿病肾病中重要的细胞间相互作用
Single-Nucleus Transcriptomic Analysis Reveals Important Cell Cross-Talk in Diabetic Kidney Disease.
作者信息
Wei Yi, Gao Xiang, Li Aihua, Liang Mengjun, Jiang Zongpei
机构信息
Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
出版信息
Front Med (Lausanne). 2021 Apr 21;8:657956. doi: 10.3389/fmed.2021.657956. eCollection 2021.
Diabetic kidney disease (DKD) leads to the loss of renal function and cell cross-talk is one of the crucial mechanisms participating in the pathogenesis of DKD. However, the mechanisms of cell communication were not fully elucidated in previous studies. In this study, we performed cell cross-talk analysis using CellPhoneDB based on a single-nucleus transcriptomic dataset (GSE131882) and revealed the associations between cell communication-related genes and renal function, providing overall insight into cell communication in DKD. In addition, this study may facilitate the discovery of novel mechanisms, promising biomarkers, and therapeutic targets that are clinically beneficial to patients.
糖尿病肾病（DKD）会导致肾功能丧失，而细胞间相互作用是参与DKD发病机制的关键机制之一。然而，细胞通讯机制在以往研究中尚未得到充分阐明。在本研究中，我们基于单核转录组数据集（GSE131882）使用CellPhoneDB进行了细胞间相互作用分析，揭示了细胞通讯相关基因与肾功能之间的关联，全面深入了解了DKD中的细胞通讯情况。此外，本研究可能有助于发现对患者具有临床益处的新机制、有前景的生物标志物和治疗靶点。
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