不同非洲人群中呼出气甲烷与大肠癌风险
Breath methane and large bowel cancer risk in contrasting African populations.
作者信息
Segal I, Walker A R, Lord S, Cummings J H
机构信息
Gastroenterology Unit, Baragwanath Hospital, South Africa.
出版信息
Gut. 1988 May;29(5):608-13. doi: 10.1136/gut.29.5.608.
Breath methane has been measured in 1016 people from four populations resident in Southern Africa which experience widely different risks of bowel cancer and other colonic diseases. Highly significant differences in the proportion of subjects with detectable methane in breath were found; % producers--rural black 84, urban black 72, white 52, Indian 41 (chi 2 121 p less than 0.001 3 df). There was a slight preponderance of female producers over male (female producers 63%, males 57%) and an age trend with fewer producers in the older age groups in the urban blacks and Indians, these comparisons being significant when tested by stepwise logistic regression analysis. Bowel cancer risk, determined from a variety of sources, was lowest in rural blacks, greatest in whites, with intermediate rates for urban blacks and Indians. Methane production in the human colon shows significant interethnic differences but which bear no relation to bowel cancer risk in these populations.
对来自南部非洲四个不同人群的1016人进行了呼出气甲烷检测，这些人群患肠癌和其他结肠疾病的风险差异很大。结果发现，呼出气中可检测到甲烷的受试者比例存在极显著差异；甲烷产生者的比例——农村黑人84%，城市黑人72%，白人52%，印度人41%（卡方值121，自由度3，P<0.001）。女性甲烷产生者略多于男性（女性产生者63%，男性57%），城市黑人和印度人年龄较大组的甲烷产生者较少，呈年龄趋势，经逐步逻辑回归分析检验，这些比较具有显著性。根据多种来源确定的患肠癌风险，农村黑人最低，白人最高，城市黑人和印度人处于中间水平。人类结肠中的甲烷产生存在显著的种族差异，但与这些人群的患肠癌风险无关。
Zotero 插件