Shin Jae Young, Park Ji Hyeon, Che Denis Nchang, Kang Hyun Ju, Cho Byoung Ok, Lim Yi Teak, Jang Seon Il
Department of Food Science and Technology, Jeonbuk National University, Jeonju-si, Jeollabuk-do 54896, Republic of Korea.
Research Institute, Ato Q&A Co., Ltd., Jeonju-si, Jeollabuk-do 54840, Republic of Korea.
Exp Ther Med. 2021 Jul;22(1):682. doi: 10.3892/etm.2021.10114. Epub 2021 Apr 25.
, , and red ginseng have been used as folk remedies for treating a variety of diseases. In the current study, the protective effects of halophyte and red ginseng against ultraviolet (UV)-induced skin damage were investigated. Halophyte red ginseng complex extract (HRCE) was prepared and its effects on UV-B irradiated human keratinocytes and mouse skin were studied through ELISA, Western blotting immunofluorescence and histological staining. HRCE inhibited peroxide-induced damage in human keratinocytes. HRCE also inhibited UVB-induced collagen and elastin degradation in human keratinocytes and mouse skin. In addition, HRCE inhibited mast cell infiltration in the skin of mice irradiated with UVB light. This effect was likely due to HRCE inhibiting the activation of MAPK and NF-κB. By protecting the skin from UVB-induced skin damage, HRCE has the potential to be used in the treatment and prevention of UV-induced skin damage and photoaging.
盐生植物和红参一直被用作治疗多种疾病的民间疗法。在当前的研究中，研究了盐生植物和红参对紫外线（UV）诱导的皮肤损伤的保护作用。制备了盐生植物红参复合提取物（HRCE），并通过酶联免疫吸附测定、蛋白质印迹免疫荧光和组织学染色研究了其对UV-B照射的人角质形成细胞和小鼠皮肤的影响。HRCE抑制了过氧化物诱导的人角质形成细胞损伤。HRCE还抑制了UVB诱导的人角质形成细胞和小鼠皮肤中胶原蛋白和弹性蛋白的降解。此外，HRCE抑制了UVB照射小鼠皮肤中的肥大细胞浸润。这种作用可能是由于HRCE抑制了丝裂原活化蛋白激酶（MAPK）和核因子κB（NF-κB）的激活。通过保护皮肤免受UVB诱导的皮肤损伤，HRCE具有用于治疗和预防UV诱导的皮肤损伤和光老化的潜力。
