Liu Xiao-Zheng, Pedersen Line, Halberg Nils
Department of Biomedicine, University of Bergen, N-5020 Bergen, Norway.
Cell Stress. 2021 Apr 12;5(5):55-72. doi: 10.15698/cst2021.05.248.
Obesity is epidemiologically linked to 13 forms of cancer. The local and systemic obese environment is complex and likely affect tumors through multiple avenues. This includes modulation of cancer cell phenotypes and the composition of the tumor microenvironment. A molecular understanding of how obesity links to cancer holds promise for identifying candidate genes for targeted therapy for obese cancer patient. Herein, we review both the cell-autonomous and non-cell-autonomous mechanisms linking obesity and cancer as well as provide an overview of the mouse model systems applied to study this.
肥胖在流行病学上与13种癌症相关。局部和全身的肥胖环境复杂，可能通过多种途径影响肿瘤。这包括对癌细胞表型和肿瘤微环境组成的调节。从分子层面理解肥胖与癌症的关联，有望为肥胖癌症患者确定靶向治疗的候选基因。在此，我们综述了将肥胖与癌症联系起来的细胞自主和非细胞自主机制，并概述了用于研究此问题的小鼠模型系统。
