Department of Medical and Surgical Sciences, University of Bologna, Via Albertoni, 15 40138, Bologna, Italy.
Medical Department of Continuity of Care and Disability, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Geroscience. 2021 Aug;43(4):2087-2100. doi: 10.1007/s11357-021-00381-7. Epub 2021 May 13.
NT-proB-type natriuretic peptide (NT-proBNP) serum concentration can be transformed by simple formulas into proBNPage, a surrogate of biological age strongly associated with chronological age, all-cause mortality, and disease count. This cross-sectional study aimed to assess whether proBNPage is also associated with other manifestations of the aging process in comparison with other variables. The study included 1117 noninstitutionalized older adults (73.1 ± 5.6 years, 537 men). Baseline measurements of serum NT-proBNP, erythrocyte sedimentation rate, hemoglobin, lymphocytes, and creatinine, which have previously been shown to be highly associated with both age and all-cause mortality, were performed. These variables were compared between subjects with and without manifestations of cardiovascular impairment (myocardial infarction (MI), stroke, peripheral artery disease (PAD), arterial revascularizations (AR)), physical impairment (long step test duration (LSTD), walking problems, falls, deficit in one or more activities of daily living), and psychological impairment (poor self-rating of health (PSRH), anxiety/depression, Mini Mental State Examination (MMSE) score < 24). ProBNPage (years) was independently associated (OR, 95% CI) with MI (1.08, 1.07-1.10), stroke (1.02, 1.00-1.05), PAD (1.04, 1.01-1.06), AR (1.06, 1.04-1.08), LSTD (1.03, 1.02-1.04), walking problems (1.02, 1.01-1.03), and PSRH (1.02, 1.01-1.02). For 5 of these 7 associations, the relationship was stronger than that of chronological age. In addition, proBNPage was univariately associated with MMSE score < 24, anxiety/depression, and falls. None of the other variables provided comparable performances. Thus, in addition to the known associations with mortality and disease count, proBNPage is also associated with cardiovascular manifestations as well as noncardiovascular manifestations of the aging process.
氨基末端 proB 型利钠肽（NT-proBNP）血清浓度可以通过简单的公式转化为 proBNPage，proBNPage 是一种与生物年龄密切相关的替代指标，与年龄、全因死亡率和疾病数量密切相关。这项横断面研究旨在评估与其他变量相比，proBNPage 是否也与衰老过程的其他表现有关。该研究纳入了 1117 名非住院老年人（73.1±5.6 岁，537 名男性）。对血清 NT-proBNP、红细胞沉降率、血红蛋白、淋巴细胞和肌酐进行了基线测量，这些指标先前已被证明与年龄和全因死亡率高度相关。比较了有和无心血管损伤表现（心肌梗死（MI）、中风、外周动脉疾病（PAD）、动脉血运重建（AR））、身体损伤（长步测试时间（LSTD）、行走问题、跌倒、一项或多项日常生活活动受损）和心理损伤（健康自评差（PSRH）、焦虑/抑郁、简易精神状态检查（MMSE）评分<24）受试者之间的这些变量。ProBNPage（岁）与 MI（1.08，1.07-1.10）、中风（1.02，1.00-1.05）、PAD（1.04，1.01-1.06）、AR（1.06，1.04-1.08）、LSTD（1.03，1.02-1.04）、行走问题（1.02，1.01-1.03）和 PSRH（1.02，1.01-1.02）独立相关（OR，95%CI）。对于这 7 个关联中的 5 个，其相关性强于年龄。此外，proBNPage 与 MMSE 评分<24、焦虑/抑郁和跌倒也有单变量关联。其他变量均未提供可比的表现。因此，除了与死亡率和疾病数量的已知关联外，proBNPage 还与心血管表现以及衰老过程的非心血管表现有关。
