Department of Microbiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
Department of Microbiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India; Manipal McGill Centre for Infectious Diseases, PSPH, Manipal, India.
Poult Sci. 2021 Jun;100(6):101094. doi: 10.1016/j.psj.2021.101094. Epub 2021 Mar 22.
The study was carried out to estimate the burden and pattern of antibiotic resistance and to identify antibiotic resistance genes with focus on ESBL producers, plasmid mediated quinolone resistance, and tetracycline efflux genes, in faecal bacterial isolates collected from poultry farms of coastal Southern Karnataka, India. High resistance to fluoroquinolones was observed with 94% Escherichia coli and 80% Klebsiella pneumoniae being resistant to both ciprofloxacin and levofloxacin. All the Escherichia coli strains were resistant to tetracycline (100%). qnrB (38%) was the most common gene detected followed by qnrS (27%) and qnrA (21.5%). All Klebsiella pneumoniae isolates resistant to tetracycline harbored tetA gene. Most of the isolates in our study had high MAR indices indicating rampant use of antibiotics.
本研究旨在评估印度南部沿海卡纳塔克邦沿海家禽养殖场粪便细菌分离株中抗生素耐药性的负担和模式，并确定以产 ESBL 菌、质粒介导的喹诺酮耐药和四环素外排基因为重点的抗生素耐药基因。研究发现，94%的大肠杆菌和 80%的肺炎克雷伯菌对环丙沙星和左氧氟沙星均具有高度耐药性，对氟喹诺酮类药物的耐药率很高。所有大肠杆菌菌株均对四环素（100%）耐药。qnrB（38%）是检测到的最常见基因，其次是 qnrS（27%）和 qnrA（21.5%）。所有对四环素耐药的肺炎克雷伯菌分离株均携带 tetA 基因。我们研究中的大多数分离株具有较高的 MAR 指数，表明抗生素的广泛使用。
