Hu Runan, Liu Zhuo, Geng Yuli, Huang Yanjing, Li Fan, Dong Haoxu, Ma Wenwen, Song Kunkun, Zhang Mingmin, Song Yufan
Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Microorganisms. 2023 Jun 30;11(7):1725. doi: 10.3390/microorganisms11071725.
Gestational diabetes mellitus (GDM) is an intractable issue that negatively impacts the quality of pregnancy. The incidence of GDM is on the rise, becoming a major health burden for both mothers and children. However, the specific etiology and pathophysiology of GDM remain unknown. Recently, the importance of gut microbiota and related metabolic molecules has gained prominence. Studies have indicated that women with GDM have significantly distinct gut microbiota and gut metabolites than healthy pregnant women. Given that the metabolic pathways of gut flora and related metabolites have a substantial impact on inflammation, insulin signaling, glucose, and lipid metabolism, and so on, gut microbiota or its metabolites, such as short-chain fatty acids, may play a significant role in both pathogenesis and progression of GDM. Whereas the role of intestinal flora during pregnancy is still in its infancy, this review aims to summarize the effects and mechanisms of gut microbiota and related metabolic molecules involved in GDM, thus providing potential intervention targets.
妊娠期糖尿病（GDM）是一个棘手的问题，会对妊娠质量产生负面影响。GDM的发病率呈上升趋势，成为母亲和儿童的主要健康负担。然而，GDM的具体病因和病理生理学仍不清楚。最近，肠道微生物群及相关代谢分子的重要性日益凸显。研究表明，患有GDM的女性与健康孕妇相比，其肠道微生物群和肠道代谢产物存在显著差异。鉴于肠道菌群及其相关代谢产物的代谢途径对炎症、胰岛素信号传导、葡萄糖和脂质代谢等有重大影响，肠道微生物群或其代谢产物，如短链脂肪酸，可能在GDM的发病机制和进展中发挥重要作用。虽然孕期肠道菌群的作用仍处于起步阶段，但本综述旨在总结肠道微生物群及相关代谢分子在GDM中的作用和机制，从而提供潜在的干预靶点。
