Pusterla Lucrezia, Radovanovic Dragana, Muggli Franco, Erne Paul, Schoenenberger Andreas W, Schoenenberger-Berzins Renate, Parati Gianfranco, Suter Paolo, Lava Sebastiano A G, Gallino Augusto, Bianchetti Mario G
Family Medicine Institute, Faculty of Biomedical Science, Università della Svizzera Italiana, Lugano, Switzerland.
Department of Geriatrics, Inselspital, Bern University Hospital, and University of Bern,, Bern, Switzerland.
Cardiol Ther. 2022 Dec;11(4):545-557. doi: 10.1007/s40119-022-00280-8. Epub 2022 Sep 24.
Cardiovascular disease is the leading cause of morbidity and mortality. Besides traditional cardiovascular risk factors, arterial stiffness is a recognized predictor of cardiovascular risk.
We investigated the relationship between traditional cardiovascular risk factors, sex, and aortic pulse wave velocity in subjects living in a countryside area of Southern Switzerland. For this aim, we performed a cross-sectional analysis of data from adult participants of the Swiss Longitudinal Cohort Study, which, initiated in 2015, follows health status and disease risk factors in a Swiss countryside cohort at least 6 years of age.
A total of 387 people (205 women and 182 men) were included. Hyperlipidemia, overweight, and obesity were more common (p ≤ 0.001) and LDL-cholesterol, triglycerides, and hemoglobin A1c were higher (p < 0.03) in men than women. Systolic and diastolic brachial and aortic blood pressures were higher in men (p < 0.02), whereas aortic pulse wave velocity and aortic pulse pressure were higher in women (p < 0.05). The aortic pulse wave velocity was significantly higher in subjects with hypertension, hyperlipidemia, diabetes, and obesity, and significantly increased with age (p < 0.0001). Multiple linear regression analysis showed a significant correlation between pulse wave velocity and age, female sex, brachial systolic blood pressure, and heart rate (p < 0.005).
Also in a countryside area, the aortic pulse wave velocity is higher in subjects with hypertension, hyperlipidemia, diabetes and obesity, and significantly increases with age. Furthermore, with advancing age, aortic pulse wave velocity is higher in women than men.
ClinicalTrials.gov identifier, NCT02282748.
心血管疾病是发病和死亡的主要原因。除了传统的心血管危险因素外，动脉僵硬度是公认的心血管风险预测指标。
我们调查了瑞士南部农村地区居民的传统心血管危险因素、性别与主动脉脉搏波速度之间的关系。为此，我们对瑞士纵向队列研究中成年参与者的数据进行了横断面分析，该研究于2015年启动，追踪至少6岁的瑞士农村队列的健康状况和疾病危险因素。
共纳入387人（205名女性和182名男性）。男性高脂血症、超重和肥胖更为常见（p≤0.001），低密度脂蛋白胆固醇、甘油三酯和糖化血红蛋白水平更高（p<0.03）。男性肱动脉收缩压和舒张压以及主动脉血压更高（p<0.02），而女性主动脉脉搏波速度和主动脉脉压更高（p<0.05）。高血压、高脂血症、糖尿病和肥胖患者的主动脉脉搏波速度显著更高，且随年龄显著增加（p<0.0001）。多元线性回归分析显示脉搏波速度与年龄、女性性别、肱动脉收缩压和心率之间存在显著相关性（p<0.005）。
同样在农村地区，高血压、高脂血症、糖尿病和肥胖患者的主动脉脉搏波速度更高，且随年龄显著增加。此外，随着年龄增长，女性的主动脉脉搏波速度高于男性。
ClinicalTrials.gov标识符，NCT02282748。
