Albajara Sáenz Ariadna, Villemonteix Thomas, Van Schuerbeek Peter, Baijot Simon, Septier Mathilde, Defresne Pierre, Delvenne Véronique, Passeri Gianfranco, Raeymaekers Hubert, Victoor Laurent, Willaye Eric, Peigneux Philippe, Deconinck Nicolas, Massat Isabelle
Neuropsychology and Functional Neuroimaging Research Group (UR2NF) at the Centre for Research in Cognition and Neurosciences, Université Libre de Bruxelles, Brussels, Belgium.
Paris 8 Vincennes - St Denis University, Laboratoire de Psychopathologie et Neuropsychologie, Saint Denis, France.
Front Neurol. 2021 May 4;12:666980. doi: 10.3389/fneur.2021.666980. eCollection 2021.
Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) are associated with motor impairments, with some children holding a comorbid diagnosis of Developmental Coordination Disorder (DCD). However, DCD is underdiagnosed in these populations and the volume abnormalities that contribute to explaining these motor impairments are poorly understood. In this study, motor abilities as measured by the Developmental Coordination Disorder Questionnaire (DCDQ) were compared between children with ADHD, children with ASD and typically developing (TD) children, aged 8-12 years old. Additionally, the association between the DCDQ scores (general coordination, fine motor/handwriting, control during movement, total) and regional volume abnormalities were explored in 6 regions of interest (pre-central gyrus, post-central gyrus, inferior parietal cortex, superior frontal gyrus, middle frontal gyrus, medial frontal gyrus), within each group and across all participants. Children with ASD and children with ADHD showed impaired motor abilities in all the DCDQ-derived scores compared to TD children. Additionally, most children with ASD or ADHD had an indication or suspicion of DCD. Within the ASD group, coordination abilities were associated with the volume of the right medial frontal gyrus, and within the ADHD group, the total DCDQ score was associated with the volume of the right superior frontal gyrus. This study underlines the importance of routinely checking motor abilities in populations with ASD or ADHD in clinical practise and contributes to the understanding of structural abnormalities subtending motor impairments in these disorders.
注意缺陷多动障碍（ADHD）和孤独症谱系障碍（ASD）与运动障碍相关，一些儿童同时被诊断为发育性协调障碍（DCD）。然而，DCD在这些人群中未得到充分诊断，导致这些运动障碍的脑容量异常也知之甚少。在本研究中，对8至12岁的ADHD儿童、ASD儿童和发育正常（TD）儿童进行了比较，通过发育性协调障碍问卷（DCDQ）来测量他们的运动能力。此外，在每组以及所有参与者中，研究了DCDQ评分（一般协调性、精细运动/书写、运动控制、总分）与6个感兴趣区域（中央前回、中央后回、顶下小叶、额上回、额中回、额内侧回）的区域脑容量异常之间的关联。与TD儿童相比,ASD儿童和ADHD儿童在所有DCDQ衍生评分中均表现出运动能力受损。此外，大多数ASD或ADHD儿童有DCD迹象或疑似DCD。在ASD组中，协调能力与右侧额内侧回的脑容量相关，在ADHD组中，DCDQ总分与右侧额上回的脑容量相关。本研究强调了在临床实践中对ASD或ADHD人群进行常规运动能力检查的重要性，并有助于理解这些疾病中运动障碍背后的结构异常。
