Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, 250012, China.
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
Colloids Surf B Biointerfaces. 2021 Sep;205:111851. doi: 10.1016/j.colsurfb.2021.111851. Epub 2021 May 14.
The surface modification of biomaterials is crucial for constructing bioactive interfaces capable of interacting with specific biomolecules, controlling cell behavior and regulating biological processes. Because of their excellent biocompatibility, facile preparation, pH-responsiveness and universal adhesion, surface coatings made from metal-phenolic network (MPN) have attracted extensive attention for handling interfacial properties and designing biomaterials in recent years. Different methods and technologies for assembling MPN coatings are summarized and compared in this paper, followed by highlighting the advantages of MPN coatings as bioactive interfaces for controlling biological process at the molecular, cellular, and tissue levels. Current challenges and prospects of MPN coatings for biomedical applications are also discussed.
生物材料的表面改性对于构建能够与特定生物分子相互作用、控制细胞行为和调节生物过程的活性界面至关重要。由于其优异的生物相容性、易于制备、pH 响应性和普遍的粘附性，近年来，由金属-酚网络（MPN）制成的表面涂层因其能够处理界面性质和设计生物材料而受到广泛关注。本文总结并比较了组装 MPN 涂层的不同方法和技术，接着强调了 MPN 涂层作为生物活性界面在分子、细胞和组织水平上控制生物过程的优势。本文还讨论了 MPN 涂层在生物医学应用方面的当前挑战和前景。
