Ye Xiaolin, Wang Dong, Zhu Huaqian, Wang Dahai, Li Jing, Tang Yanqing, Wu Jie
Department of Gastroenterology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.
Front Psychiatry. 2021 May 7;12:641491. doi: 10.3389/fpsyt.2021.641491. eCollection 2021.
Vortioxetine hydrobromide is a common clinical medication for major depressive disorder (MDD). However, it remains unclear whether vortioxetine hydrobromide acts by affecting the structure and composition of gut microbiota. Here, we analyzed fecal samples from 28 healthy controls (HCs) and 26 patients with MDD before treatment with vortioxetine hydrobromide, at 4 weeks after treatment, and at 8 weeks after treatment. High-throughput pyrosequencing showed that, according to the Chao1 and Shannon indices, fecal bacterial α-diversity was higher in the patients with MDD than in the HCs ( < 0.05), but no significant differences were observed after vortioxetine hydrobromide treatment ( > 0.05). PCoA results revealed that the gut microbiota composition was significantly different between the MDD groups and HCs. Proteobacteria and Actinobacteria were strongly increased, whereas Firmicutes were significantly reduced in the MDD group compared with the HCs. After treatment with vortioxetine hydrobromide, Firmicutes were significantly increased, and the proportion of Bacteroidetes decreased. Most notably, , and were negatively correlated with the severity of depressive symptoms. Taken together, our data indicate changes in the fecal microbiota composition in MDD patients compared with HCs, and vortioxetine hydrobromide may treat MDD through regulation of the gut microflora.
氢溴酸伏硫西汀是治疗重度抑郁症（MDD）的一种常用临床药物。然而，氢溴酸伏硫西汀是否通过影响肠道微生物群的结构和组成发挥作用仍不清楚。在此，我们分析了28名健康对照者（HCs）和26例MDD患者在接受氢溴酸伏硫西汀治疗前、治疗后4周和治疗后8周的粪便样本。高通量焦磷酸测序显示，根据Chao1和Shannon指数，MDD患者粪便细菌的α多样性高于HCs（<0.05），但在氢溴酸伏硫西汀治疗后未观察到显著差异（>0.05）。主坐标分析（PCoA）结果显示，MDD组和HCs之间的肠道微生物群组成存在显著差异。与HCs相比，MDD组中变形菌门和放线菌门显著增加，而厚壁菌门显著减少。氢溴酸伏硫西汀治疗后，厚壁菌门显著增加，拟杆菌门比例下降。最值得注意的是，[此处原文缺失具体菌名]与抑郁症状的严重程度呈负相关。综上所述，我们的数据表明，与HCs相比，MDD患者的粪便微生物群组成发生了变化，氢溴酸伏硫西汀可能通过调节肠道微生物群来治疗MDD。
