de Mouzon J, Spira A, Schwartz D
INSERM U 292, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
Int J Epidemiol. 1988 Jun;17(2):378-84. doi: 10.1093/ije/17.2.378.
A prospective study of fertility was conducted from 1977 to 1982. Analysis of the relation between cigarette smoking and occurrence of a pregnancy was performed on 1887 couples. The actuarial pregnancy rate was 82.9% at the end of a year. Cigarette smoking by both members of the couple was found to be related to decreased fertility when this factor was considered alone. But after including all the confounding covariates in a Cox semi-proportional hazards model for survival data, no relationship remained between cigarette smoking and fertility. Odds ratios were respectively 0.86 (95% confidence interval: 0.63, 1.19) and 0.99 (0.85, 1.14) for women smoking and men smoking. This could suggest that the relationship found by other authors might be at least partly explained by a relation between cigarette smoking and other factors related to fertility.
1977年至1982年进行了一项关于生育能力的前瞻性研究。对1887对夫妇进行了吸烟与怀孕发生之间关系的分析。一年结束时的精算妊娠率为82.9%。当单独考虑这个因素时，发现夫妇双方吸烟与生育能力下降有关。但在将所有混杂协变量纳入生存数据的Cox半比例风险模型后，吸烟与生育能力之间不再存在关系。女性吸烟和男性吸烟的优势比分别为0.86（95%置信区间：0.63，1.19）和0.99（0.85，1.14）。这可能表明其他作者发现的关系可能至少部分是由吸烟与其他生育相关因素之间的关系所解释的。
