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miR-510在结肠癌预后及发展中的价值

The value of miR-510 in the prognosis and development of colon cancer.

作者信息

Hang Junjie, Wei Feifei, Yan Zhiying, Zhang Xianming, Xu Kequn, Zhu Yingwei

机构信息

Department of Oncology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213003, People's Republic of China.

出版信息

Open Med (Wars). 2021 May 15;16(1):795-804. doi: 10.1515/med-2021-0251. eCollection 2021.

DOI:10.1515/med-2021-0251
PMID:34036176
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8126670/
Abstract

PURPOSE

Colon cancer is one of the malignant tumors that threatens human health. miR-510 was demonstrated to play roles in the progression of various cancers; its dysregulation was speculated to be associated with the development of colon cancer.

METHODS

One hundred and thirteen colon cancer patients participated in this research. With the help of RT-qPCR, the expression of miR-510 in collected tissues and cultured cells was analyzed. The association between miR-510 expression level and clinical features and prognosis of patients was evaluated. Moreover, the effects of miR-510 on cell proliferation, migration, and invasion of colon cancer were assessed by CCK8 and Transwell assay.

RESULTS

miR-510 significantly upregulated in colon cancer tissues and cell lines relative to the adjacent normal tissues and colonic cells. The expression of miR-510 was significantly associated with the TNM stage and poor prognosis of patients, indicating miR-510 was involved in the disease progression and clinical prognosis of colon cancer. Additionally, the upregulation of miR-510 significantly promoted cell proliferation, migration, and invasion of colon cancer, while its knockdown significantly inhibited these cellular processes. SRCIN 1 was the direct target of miR-510 during its promoted effect on the development of colon cancer.

CONCLUSION

The upregulation of miR-510 acts as an independent prognostic indicator and a tumor promoter by targeting SRCIN 1 in colon cancer, which provides novel therapeutic strategies for colon cancer.

摘要

目的

结肠癌是威胁人类健康的恶性肿瘤之一。已证明miR-510在多种癌症进展中发挥作用；推测其失调与结肠癌的发生发展有关。

方法

113例结肠癌患者参与本研究。借助RT-qPCR分析收集组织和培养细胞中miR-510的表达。评估miR-510表达水平与患者临床特征及预后的相关性。此外，通过CCK8和Transwell实验评估miR-510对结肠癌细胞增殖、迁移和侵袭的影响。

结果

与相邻正常组织和结肠细胞相比，miR-510在结肠癌组织和细胞系中显著上调。miR-510的表达与患者的TNM分期及不良预后显著相关，表明miR-510参与了结肠癌的疾病进展和临床预后。此外，miR-510的上调显著促进结肠癌细胞的增殖、迁移和侵袭，而其敲低则显著抑制这些细胞过程。SRCIN 1是miR-510在促进结肠癌发展过程中的直接靶点。

结论

miR-510的上调通过靶向结肠癌中的SRCIN 1作为独立的预后指标和肿瘤促进因子，为结肠癌提供了新的治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/fbe950bd20e1/j_med-2021-0251-fig007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/bd25dc20c9cb/j_med-2021-0251-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/0be6b20f90b0/j_med-2021-0251-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/308782905722/j_med-2021-0251-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/4862b4a2f6cf/j_med-2021-0251-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/eaff1343468f/j_med-2021-0251-fig005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/cb2b769b48d7/j_med-2021-0251-fig006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/fbe950bd20e1/j_med-2021-0251-fig007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/bd25dc20c9cb/j_med-2021-0251-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/0be6b20f90b0/j_med-2021-0251-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/308782905722/j_med-2021-0251-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/4862b4a2f6cf/j_med-2021-0251-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/eaff1343468f/j_med-2021-0251-fig005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/cb2b769b48d7/j_med-2021-0251-fig006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b05/8126670/fbe950bd20e1/j_med-2021-0251-fig007.jpg

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