精准医学时代的转化生物标志物。
Translational biomarkers in the era of precision medicine.
机构信息
Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom; Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom.
Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom; Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom; NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospital Birmingham, Birmingham, United Kingdom.
出版信息
Adv Clin Chem. 2021;102:191-232. doi: 10.1016/bs.acc.2020.08.002. Epub 2020 Oct 3.
In this chapter we discuss the past, present and future of clinical biomarker development. We explore the advent of new technologies, paving the way in which health, medicine and disease is understood. This review includes the identification of physicochemical assays, current regulations, the development and reproducibility of clinical trials, as well as, the revolution of omics technologies and state-of-the-art integration and analysis approaches.
在本章中，我们讨论了临床生物标志物开发的过去、现在和未来。我们探讨了新技术的出现，为人们理解健康、医学和疾病开辟了新的途径。本综述包括物理化学分析方法的鉴定、现行法规、临床试验的开发和重现性，以及组学技术的革命和最先进的集成与分析方法。
Zotero 插件