Acharjee Animesh
College of Medical and Dental Sciences, Institute of Cancer and Genomic Sciences, University of Birmingham, B15 2TT, Birmingham, UK.
Institute of Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, B15 2TH, Birmingham, UK.
Adv Biomark Sci Technol. 2023;5:86-88. doi: 10.1016/j.abst.2023.10.002.
The physiologic and irreversible process of ageing is accompanied by a wide range of structural and functional shifts at multiple different levels. It is also suggested that variations in the blood concentrations of metabolites, hormones, and micronutrients may play a role in the ageing process. Recently, Singh et al. investigated a study on Taurine shortage as a driver and biomarker of ageing and its impact on a healthy lifespan. They further proposed that functional abnormalities in numerous organs associated with age-related illnesses have been linked to early-life Taurine insufficiency. Taurine deficiency in the elderly and the possible benefits of Taurine supplements One of the reasons for decreasing Taurine concentration is the loss of endogenous synthesis, which may contribute to the decrease in Taurine levels seen in the elderly. While it was previously believed that the liver was responsible for most Taurine synthesis in humans, new research suggests that other organs or common intermediates may play a larger role. The authors experimented with and analysed a life-span examination of various organisms, for example, mice to assess the impacts of Taurine supplementation. They also analysed after the administration of oral Taurine supplementation in conjunction with other interventions using multi-omics data sets (RNA sequencing, metabolomics etc.) across different species.
衰老这一生理上不可逆转的过程伴随着多个不同层面广泛的结构和功能变化。也有人提出，代谢物、激素和微量营养素的血液浓度变化可能在衰老过程中发挥作用。最近，辛格等人开展了一项关于牛磺酸缺乏作为衰老驱动因素和生物标志物及其对健康寿命影响的研究。他们进一步提出，与年龄相关疾病相关的众多器官功能异常与生命早期牛磺酸不足有关。老年人的牛磺酸缺乏及牛磺酸补充剂的潜在益处 牛磺酸浓度降低的原因之一是内源性合成的丧失，这可能导致老年人牛磺酸水平下降。虽然之前认为肝脏是人类牛磺酸合成的主要场所，但新研究表明其他器官或常见中间产物可能发挥更大作用。作者对各种生物体（如小鼠）进行了寿命试验并分析，以评估补充牛磺酸的影响。他们还在口服补充牛磺酸并结合其他干预措施后，使用跨不同物种的多组学数据集（RNA测序、代谢组学等）进行了分析。
