Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
NIHR Cambridge Biomedical Research Centre-Diet, Anthropometry and Physical Activity Group, MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
J Obes. 2021 May 15;2021:6634536. doi: 10.1155/2021/6634536. eCollection 2021.
Reference values for visceral adipose tissue (VAT) are needed and it has been advocated that body composition measures depend on both the technique and methods applied, as well as the population of interest. We aimed to develop reference values for VAT in absolute grams (VATg), percent (VAT%), and as a kilogram-per-meters-squared index (VATindex) for women and men, and investigate potential differences between these measures and their associations with cardiometabolic risk factors (including metabolic syndrome (MetS)).
In the seventh survey of the population-based Tromsø Study, 3675 participants (aged 40-84, 59% women) attended whole-body DXA scans (Lunar Prodigy GE) from where VAT was derived. We used descriptive analysis, correlations, receiver operating characteristics (ROC), and logistic regression to propose reference values for VAT and investigated VAT's association with cardiometabolic risk factors, MetS and single MetS components. Further, Youden's index was used to suggest threshold values for VAT.
VATg and VATindex increased until age 70 and then decreased, while VAT% increased with age across all age groups. VAT (all measurement units) was moderate to highly correlated and significantly associated with all cardiometabolic risk factors, except for total cholesterol. Associations between MetS, single MetS components, and VATg and VATindex were similar, and VAT% did not contribute any further to this association.
These VAT reference values and thresholds, developed in a sample of adults of Norwegian origin, could be applied to other studies with similar populations using the same DXA device and protocols. The associations between VAT and cardiometabolic risk factors were similar across different measurement units of VAT.
需要内脏脂肪组织 (VAT) 的参考值，有人主张身体成分测量值取决于所应用的技术和方法，以及感兴趣的人群。我们旨在为女性和男性的绝对克 (VATg)、百分比 (VAT%) 和每平方米公斤指数 (VATindex) 的 VAT 制定参考值，并研究这些措施之间的潜在差异及其与心血管代谢危险因素（包括代谢综合征 (MetS)) 的关联。
在基于人群的特罗姆瑟研究第七次调查中，3675 名参与者（年龄 40-84 岁，59%为女性）接受了全身 DXA 扫描（Lunar Prodigy GE），从中得出了 VAT。我们使用描述性分析、相关性、受试者工作特征 (ROC) 和逻辑回归来提出 VAT 的参考值，并研究了 VAT 与心血管代谢危险因素、MetS 和单个 MetS 成分的关联。此外，还使用约登指数建议了 VAT 的阈值值。
VATg 和 VATindex 一直增加到 70 岁，然后开始下降，而 VAT% 在所有年龄段都随年龄增加而增加。VAT（所有测量单位）具有中度到高度相关性，与所有心血管代谢危险因素显著相关，除了总胆固醇。MetS、单个 MetS 成分和 VATg 和 VATindex 之间的关联相似，而 VAT% 对此关联没有进一步贡献。
这些在具有挪威血统的成年人样本中开发的 VAT 参考值和阈值可应用于使用相同 DXA 设备和方案的其他具有相似人群的研究。VAT 与心血管代谢危险因素之间的关联在不同的 VAT 测量单位之间相似。
