Melchor-Martínez Elda M, Torres Castillo Nora E, Macias-Garbett Rodrigo, Lucero-Saucedo Sofia Liliana, Parra-Saldívar Roberto, Sosa-Hernández Juan Eduardo
Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Mexico.
Front Bioeng Biotechnol. 2021 May 14;9:597958. doi: 10.3389/fbioe.2021.597958. eCollection 2021.
Over the past years, biomaterials-based nano cues with multi-functional characteristics have been engineered with high interest. The ease in fine tunability with maintained compliance makes an array of nano-bio materials supreme candidates for the biomedical sector of the modern world. Moreover, the multi-functional dimensions of nano-bio elements also help to maintain or even improve the patients' life quality most securely by lowering or diminishing the adverse effects of in practice therapeutic modalities. Therefore, engineering highly efficient, reliable, compatible, and recyclable biomaterials-based novel corrective cues with multipurpose applications is essential and a core demand to tackle many human health-related challenges, e.g., the current COVID-19 pandemic. Moreover, robust engineering design and properly exploited nano-bio materials deliver wide-ranging openings for experimentation in the field of interdisciplinary and multidisciplinary scientific research. In this context, herein, it is reviewed the applications and potential on tissue engineering and therapeutics of COVID-19 of several biomaterials. Following a brief introduction is a discussion of the drug delivery routes and mechanisms of biomaterials-based nano cues with suitable examples. The second half of the review focuses on the mainstream applications changing the dynamics of 21st century materials. In the end, current challenges and recommendations are given for a healthy and foreseeable future.
在过去几年中，具有多功能特性的基于生物材料的纳米线索已被精心设计出来，并引起了人们的高度关注。其易于精细调节且能保持顺应性，使得一系列纳米生物材料成为现代生物医学领域的绝佳候选者。此外，纳米生物元素的多功能维度还通过降低或减少实际治疗方式的副作用，最可靠地帮助维持甚至提高患者的生活质量。因此，设计具有多用途应用的高效、可靠、兼容且可回收的基于生物材料的新型矫正线索，对于应对许多与人类健康相关的挑战（例如当前的新冠疫情）至关重要且是核心需求。此外，强大的工程设计和合理利用的纳米生物材料为跨学科和多学科科学研究领域的实验提供了广泛的机会。在此背景下，本文综述了几种生物材料在组织工程和新冠治疗方面的应用及潜力。在简要介绍之后，将通过合适的例子讨论基于生物材料的纳米线索的药物递送途径和机制。综述的后半部分重点关注改变21世纪材料动态的主流应用。最后，针对健康且可预见的未来给出了当前面临的挑战和建议。
