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与隐形眼镜护理液结合的银纳米颗粒可能会降低角膜炎的风险。

Silver Nanoparticles Conjugated with Contact Lens Solutions May Reduce the Risk of Keratitis.

作者信息

Hendiger Edyta B, Padzik Marcin, Sifaoui Inés, Reyes-Batlle María, López-Arencibia Atteneri, Zyskowska Diana, Grodzik Marta, Pietruczuk-Padzik Anna, Hendiger Jacek, Olędzka Gabriela, Chomicz Lidia, Piñero José E, Lorenzo-Morales Jacob

机构信息

Department of Medical Biology, Medical University of Warsaw, Litewska 14/16, 00-575 Warsaw, Poland.

Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Departamento de Obstetricia, Ginecología, Pediatría, Medicina Preventiva y Salud Pública, Toxicología, Medicina Legal y Forense y Parasitología, Universidad de La Laguna, Av. Astrofísico Francisco Sánchez S/N, 38203 Tenerife, Spain.

出版信息

Pathogens. 2021 May 11;10(5):583. doi: 10.3390/pathogens10050583.

DOI:10.3390/pathogens10050583
PMID:34064555
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8151187/
Abstract

keratitis (AK), a severe sight-threatening corneal infection, has become a significant medical problem, especially among contact lens wearers. The disease manifests as eye pain, congestion, blurred vision, lachrymation, and ring-shaped infiltrates of the cornea, and can lead to permanent blindness. Inappropriate habits of contact lens users may result in an increased risk of AK infection. The anti-amoebic efficiency of popular multipurpose contact lens solutions is insufficient to reduce this risk. An effective and non-toxic therapy against AK has not yet been developed. The prevention of AK is crucial to reduce the number of AK infections. Nanoparticles are known to be active agents against bacteria, viruses, and fungi and were also recently tested against protozoa, including spp. In our previous studies, we proved the anti-amoebic and anti-adhesive activity of silver nanoparticles against . The aim of this study is to evaluate the activity, cytotoxicity, and anti-adhesive properties of silver nanoparticles conjugated with five commonly used multipurpose contact lens solutions against the NEFF strain. The obtained results show a significant increase in anti-amoebic activity, without increasing the overall cytotoxicity, of Solo Care Aqua and Opti Free conjugated with nanoparticles. The adhesion of trophozoites to the contact lens surface is also significantly reduced. We conclude that low concentrations of silver nanoparticles can be used as an ingredient in contact lens solutions to decrease the risk of keratitis infection.

摘要

棘阿米巴角膜炎（AK）是一种严重威胁视力的角膜感染疾病，已成为一个重大的医学问题，尤其是在隐形眼镜佩戴者中。该疾病表现为眼痛、充血、视力模糊、流泪以及角膜呈环形浸润，可导致永久性失明。隐形眼镜使用者的不当习惯可能会增加患AK感染的风险。常用的多功能隐形眼镜护理液的抗阿米巴效率不足以降低这种风险。目前尚未开发出一种有效且无毒的治疗AK的方法。预防AK对于减少AK感染的数量至关重要。已知纳米颗粒是对抗细菌、病毒和真菌的活性剂，最近也针对包括棘阿米巴属在内的原生动物进行了测试。在我们之前的研究中，我们证明了银纳米颗粒对棘阿米巴的抗阿米巴和抗黏附活性。本研究的目的是评估与五种常用多功能隐形眼镜护理液结合的银纳米颗粒对棘阿米巴NEFF菌株的活性、细胞毒性和抗黏附特性。所得结果表明，与纳米颗粒结合的Solo Care Aqua和Opti Free护理液的抗阿米巴活性显著提高，而总体细胞毒性并未增加。棘阿米巴滋养体在隐形眼镜表面的黏附也显著减少。我们得出结论，低浓度的银纳米颗粒可作为隐形眼镜护理液的一种成分，以降低棘阿米巴角膜炎感染的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/a7283a94c798/pathogens-10-00583-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/7a5a2372dea8/pathogens-10-00583-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/0434ce47e122/pathogens-10-00583-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/02188131d620/pathogens-10-00583-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/a8e318f71e2a/pathogens-10-00583-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/5d12216b5d19/pathogens-10-00583-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/2ae9fa049666/pathogens-10-00583-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/0e592b7170ad/pathogens-10-00583-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/a7283a94c798/pathogens-10-00583-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/7a5a2372dea8/pathogens-10-00583-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/0434ce47e122/pathogens-10-00583-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/02188131d620/pathogens-10-00583-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/a8e318f71e2a/pathogens-10-00583-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/5d12216b5d19/pathogens-10-00583-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/2ae9fa049666/pathogens-10-00583-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/0e592b7170ad/pathogens-10-00583-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4856/8151187/a7283a94c798/pathogens-10-00583-g008.jpg

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