Department of Medicine II and L Boiculese, Department of Interdisciplinary Medicine, University of Medicine and Pharmacy Grigore T Popa, 700115 Iasi, Romania.
Department 10 Surgery, University of Medicine and Pharmacy Carol Davila, 020021 Bucharest, Romania.
Medicina (Kaunas). 2021 May 11;57(5):474. doi: 10.3390/medicina57050474.
: In advanced chronic obstructive pulmonary disease (COPD), functional status is significantly impaired mainly as a result of disease related respiratory symptoms such as dyspnea or as a result of fatigue, which is the extra-respiratory symptom the most prevalent in this setting. "Physical" frailty, considered to be an aging phenotype, has defining traits that can also be considered when studying impaired functional status, but little is known about this relationship in advanced COPD. This review discusses the relevance of this type of frailty in advanced COPD and evaluates it utility and its clinical applicability as a potential outcome measure in palliative care for COPD. : A conceptual review on the functional status as an outcome measure of mortality and morbidity in COPD, and an update on the definition and traits of frailty. : Data on the prognostic role of frailty in COPD are rather limited, but individual data on traits of frailty demonstrating their relationship with mortality and morbidity in advanced COPD are available and supportive. : Frailty assessment in COPD patients is becoming a relevant issue not only for its potential prognostic value for increased morbidity or for mortality, but also for its potential role as a measure of functional status in palliative care for advanced COPD.
在晚期慢性阻塞性肺疾病（COPD）中，功能状态显著受损，主要是由于疾病相关的呼吸系统症状，如呼吸困难，或由于疲劳，这是该环境中最常见的呼吸系统外症状。“身体”脆弱性被认为是一种衰老表型，具有明确的特征，在研究功能状态受损时也可以考虑这些特征，但关于晚期 COPD 中这种相关性知之甚少。这篇综述讨论了这种类型的脆弱性在晚期 COPD 中的相关性，并评估了它作为 COPD 姑息治疗潜在结局指标的效用及其临床适用性。
本文对功能状态作为 COPD 死亡率和发病率的结局指标进行了概念性综述，并更新了脆弱性的定义和特征。
关于脆弱性在 COPD 中的预后作用的数据相当有限，但有关脆弱性特征的个体数据表明它们与晚期 COPD 中的死亡率和发病率相关，这是有支持依据的。
在 COPD 患者中进行脆弱性评估不仅对于增加发病率或死亡率的潜在预后价值具有重要意义，而且对于晚期 COPD 姑息治疗中功能状态的测量也具有潜在作用。
