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从伊朗真菌 CCTU A372 中分离得到的五个四氢酸衍生物。

Five Tetramic Acid Derivatives Isolated from the Iranian Fungus   CCTU A372.

机构信息

Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124 Braunschweig, Germany.

Research Center for Chemistry, Indonesian Institute of Sciences (LIPI), Kawasan Puspiptek, Serpong, 15314 Tangerang Selatan, Indonesia.

出版信息

Biomolecules. 2021 May 22;11(6):783. doi: 10.3390/biom11060783.

DOI:10.3390/biom11060783
PMID:34067463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8224775/
Abstract

Submerged mycelial cultures of the ascomycete   CCTU A372 were found to produce five previously undescribed tetramic acids, for which we propose the trivial names colposetins A-C (-) and colpomenoic acids A and B ( and ), along with the known compounds penicillide () and monodictyphenone (). The planar structures of - were determined by high-resolution electrospray ionization mass spectrometry (HR-ESIMS) and extensive 1D and 2D nuclear magnetic resonance (NMR) spectroscopy. Their absolute configurations were determined by the combination of electronic circular dischroism (ECD) analysis, -based configurational analysis, and a rotating-frame Overhauser effect spectroscopy (ROESY) experiment. Colposetin B displayed weak antimicrobial activity against and (MIC 67 µg/mL).

摘要

水浸没培养的子囊菌 CCTU A372 产生了五种以前未描述的四氢酸，我们为其提议了俗名：colposetins A-C(-) 和 colpomenoic acids A 和 B( 和 )，以及已知化合物 penicillide()和 monodictyphenone()。通过高分辨电喷雾电离质谱 (HR-ESIMS) 和广泛的 1D 和 2D 核磁共振 (NMR) 光谱确定了 - 的平面结构。通过电子圆二色性 (ECD) 分析、基于的构象分析以及旋转框架 Overhauser 效应光谱 (ROESY) 实验相结合的方式确定了它们的绝对构型。Colposetin B 对 和 显示出较弱的抗菌活性 (MIC 67 µg/mL)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e6/8224775/c5b49f66c541/biomolecules-11-00783-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e6/8224775/1814ec5b9828/biomolecules-11-00783-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e6/8224775/8113890a16bf/biomolecules-11-00783-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e6/8224775/d06bdcbe8e22/biomolecules-11-00783-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e6/8224775/ab64e405805b/biomolecules-11-00783-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e6/8224775/75b1e45c66fd/biomolecules-11-00783-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e6/8224775/c5b49f66c541/biomolecules-11-00783-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e6/8224775/1814ec5b9828/biomolecules-11-00783-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e6/8224775/8113890a16bf/biomolecules-11-00783-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e6/8224775/d06bdcbe8e22/biomolecules-11-00783-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e6/8224775/ab64e405805b/biomolecules-11-00783-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e6/8224775/75b1e45c66fd/biomolecules-11-00783-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08e6/8224775/c5b49f66c541/biomolecules-11-00783-g006.jpg

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