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用于抗菌应用的多孔聚乳酸/聚乙二醇/姜黄素复合纳米纤维的制备、表征及性能

Preparation, Characterization and Properties of Porous PLA/PEG/Curcumin Composite Nanofibers for Antibacterial Application.

作者信息

Wang Feifei, Sun Zhaoyang, Yin Jing, Xu Lan

机构信息

National Engineering Laboratory for Modern Silk, College of Textile and Engineering, Soochow University, 199 Ren-ai Road, Suzhou 215123, China.

出版信息

Nanomaterials (Basel). 2019 Apr 2;9(4):508. doi: 10.3390/nano9040508.

DOI:10.3390/nano9040508
PMID:30986938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6523786/
Abstract

Polylactide/polyethylene glycol/curcumin (PLA/PEG/Cur) composite nanofibers (CNFs) with varying ratios of PEG were successfully fabricated by electrospinning. Characterizations of the samples, such as the porous structure, crystalline structure, pore size, wetting property and Cur release property were investigated by a combination of scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and UV spectrophotometer. The antibacterial properties of the prepared porous CNFs against bacteria were studied. The results showed that with the decrease of PEG in the CNFs, there appeared an evident porous structure on the CNF surface, and the porous structure could enhance the release properties of Cur from the CNFs. When the weight ratio (PEG:PLA) was 1:9, the pore structure of the nanofiber surface became most evident and the amount of Cur released was highest. However, the antibacterial effect of nonporous CNFs was better due to burst release over a short period of time. That meant that the porous structure of the CNFs could reduce the burst release and provide better control over the drug release.

摘要

通过静电纺丝成功制备了具有不同聚乙二醇（PEG）比例的聚丙交酯/聚乙二醇/姜黄素（PLA/PEG/Cur）复合纳米纤维（CNF）。通过扫描电子显微镜（SEM）、傅里叶变换红外（FTIR）光谱、X射线衍射（XRD）和紫外分光光度计相结合的方法，对样品的多孔结构、晶体结构、孔径、润湿性和姜黄素释放性能等进行了表征。研究了制备的多孔CNF对细菌的抗菌性能。结果表明，随着CNF中PEG含量的降低，CNF表面出现明显的多孔结构，且该多孔结构可增强姜黄素从CNF中的释放性能。当重量比（PEG:PLA）为1:9时，纳米纤维表面的孔结构最为明显，姜黄素释放量最高。然而，由于短时间内的突释，无孔CNF的抗菌效果更好。这意味着CNF的多孔结构可以减少突释并更好地控制药物释放。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/ff033c5526ba/nanomaterials-09-00508-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/2cb4e574e6fe/nanomaterials-09-00508-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/d2e5ca3646e7/nanomaterials-09-00508-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/e53e439df9fe/nanomaterials-09-00508-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/9b1c811aef6a/nanomaterials-09-00508-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/7797345758bc/nanomaterials-09-00508-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/b873d1e34ddf/nanomaterials-09-00508-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/ff033c5526ba/nanomaterials-09-00508-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/2cb4e574e6fe/nanomaterials-09-00508-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/d2e5ca3646e7/nanomaterials-09-00508-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/e53e439df9fe/nanomaterials-09-00508-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/9b1c811aef6a/nanomaterials-09-00508-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/7797345758bc/nanomaterials-09-00508-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/b873d1e34ddf/nanomaterials-09-00508-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d156/6523786/ff033c5526ba/nanomaterials-09-00508-g008.jpg

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