Discipline of Hematology, Department of Internal Medicine, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Timis County, Romania.
Department of Functional Science, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Timis County, Romania.
Int J Environ Res Public Health. 2021 May 19;18(10):5444. doi: 10.3390/ijerph18105444.
Although the survival rate of patients diagnosed with multiple myeloma has doubled over the last few decades, due to the introduction of new therapeutic lines and improvement of care, other potential contributors to the therapeutic response/relapse of disease, such as nutrient intake, along with nutrition knowledge, have not been assessed during the course of the disease. The purpose of this research was to assess nutrition knowledge and diet quality in a group of patients with a diagnosis of multiple myeloma. Anthropometric, clinical and biological assessments and skeletal survey evaluations, along with the assessment of nutritional intake and general nutrition knowledge, were performed on 61 patients with a current diagnosis of multiple myeloma. A low carbohydrate diet score was computed, classified in tertiles, and used as a factor in the analysis. Patients in tertiles indicative of high carbohydrate or low carbohydrate intake showed significant alteration of clinical parameters, such as hemoglobin, uric acid, albumin, total proteins, beta-2 microglobulin, percentage of plasmacytes in the bone marrow and D-dimers, compared to patients in the medium carbohydrate intake tertile. Nutrition knowledge was not associated with clinical indicators of disease status, nor with patterns of nutrient intake. Better knowledge of food types and nutritional value of foods, along with personalized nutritional advice, could encourage patients with MM to make healthier decisions that might extend survival.
尽管过去几十年中多发性骨髓瘤患者的生存率提高了一倍，这要归功于新的治疗方案的引入和护理的改善，但其他可能影响疾病治疗反应/复发的因素，如营养摄入以及营养知识，在疾病过程中并未得到评估。本研究旨在评估一组多发性骨髓瘤患者的营养知识和饮食质量。对 61 名确诊为多发性骨髓瘤的患者进行了人体测量、临床和生物学评估以及骨骼检查评估，同时评估了营养摄入和一般营养知识。计算了低碳水化合物饮食评分，并将其分类为三分位数，并作为分析的一个因素。与摄入中碳水量的患者相比，摄入高碳水量或低碳水量的患者的临床参数（如血红蛋白、尿酸、白蛋白、总蛋白、β-2 微球蛋白、骨髓浆细胞百分比和 D-二聚体）发生了显著变化。营养知识与疾病状态的临床指标无关，也与营养素摄入模式无关。更好地了解食物类型和食物的营养价值，并提供个性化的营养建议，可以鼓励 MM 患者做出更健康的决策，从而延长生存时间。
