Feldmann H, Kretzschmar E, Klingeborn B, Rott R, Klenk H D, Garten W
Institut für Virologie, Philipps-Universität, Marburg, Germany.
Virology. 1988 Aug;165(2):428-37. doi: 10.1016/0042-6822(88)90586-7.
The primary structure of the hemagglutinin of the apathogenic avian influenza virus A/chick/Germany/N/49 (H10N7) and of the serologically related strain A/mink/Sweden/84 (H10N4) pathogenic for mink has been elucidated by nucleotide sequence analysis, and the carbohydrates attached to the polypeptide have been determined. The H10 hemagglutinin has 65, 52, 46, 45, and 44% amino acid sequence homology with serotypes H7, H3, H1, H2, and H5, respectively. H10 and H7 hemagglutinins are also most closely related in their glycosylation patterns. There is a high sequence homology between both H10 strains supporting the concept that the mink virus has obtained its hemagglutinin from an avian strain. The sequence homology includes the cleavage site which consists of a single arginine as is the case with most other hemagglutinins exhibiting low susceptibility to proteolytic activation. The similarity in hemagglutinin structure between both H10 strains is discussed in light of the distinct differences in the pathogenicity of both viruses.
通过核苷酸序列分析阐明了无致病性禽流感病毒A/鸡/德国/N/49（H10N7）以及对水貂有致病性的血清学相关毒株A/水貂/瑞典/84（H10N4）血凝素的一级结构，并确定了与该多肽相连的碳水化合物。H10血凝素与血清型H7、H3、H1、H2和H5的氨基酸序列同源性分别为65%、52%、46%、45%和44%。H10和H7血凝素在糖基化模式上也最为相似。两种H10毒株之间存在高度的序列同源性，这支持了水貂病毒的血凝素来源于禽毒株的观点。序列同源性包括裂解位点，该位点由单个精氨酸组成，这与大多数其他对蛋白水解激活敏感性较低的血凝素情况相同。结合两种病毒致病性的明显差异，讨论了两种H10毒株血凝素结构的相似性。
