Berg M, Englund L, Abusugra I A, Klingeborn B, Linné T
Department of Veterinary Microbiology, Swedish University of Agricultural Sciences, Biomedicum, Uppsala.
Arch Virol. 1990;113(1-2):61-71. doi: 10.1007/BF01318353.
Strains of an influenza H10N4 virus have been isolated during an outbreak of a respiratory disease in mink on the south-east coast of Sweden. This was the first example of a disease in mammals caused by the H10 subtype. We compared the A/mink/Sweden/84 strain with two recent avian H10N4 isolates, one from fowl and another from a mallard, both isolated in Great Britain in 1985 as well as the prototype A/chicken/Germany/N/49 (H10N7). The comparison was carried out by genomic analysis of the strains by oligonucleotide fingerprinting and in bioassays on mink. The oligonucleotide fingerprint analysis revealed a high degree of genomic homology of around 98% between the viruses from mink, mallard and fowl. Only the recent avian isolates, that from the mallard and fowl could infect mink by contact, causing similar pathological and clinical signs and inducing seroconversion as did the mink virus. However, the susceptibility of mink to the fowl and mallard viruses by contact was less pronounced than that to the mink virus. Both the genomic homology and the similarities from the infectivity and pathogenicity studies between the mink virus and the recent avian isolates point to a direct invasion of the mink population by an avian H10N4 virus.
在瑞典东南沿海水貂的一次呼吸道疾病暴发期间，分离出了H10N4流感病毒毒株。这是H10亚型引起的哺乳动物疾病的首个实例。我们将A/水貂/瑞典/84毒株与1985年在英国分离出的两株近期禽H10N4毒株（一株来自家禽，另一株来自绿头鸭）以及原型毒株A/鸡/德国/N/49（H10N7）进行了比较。通过寡核苷酸指纹图谱对毒株进行基因组分析，并在水貂身上进行生物测定来开展比较。寡核苷酸指纹分析显示，来自水貂、绿头鸭和家禽的病毒之间基因组同源性很高，约为98%。只有近期的禽分离株，即来自绿头鸭和家禽的分离株，能够通过接触感染水貂，引起与水貂病毒相似的病理和临床症状并诱导血清转化。然而，水貂通过接触对家禽和绿头鸭病毒的易感性不如对水貂病毒那么明显。水貂病毒与近期禽分离株之间的基因组同源性以及感染性和致病性研究中的相似性均表明，禽H10N4病毒直接侵入了水貂种群。
