The College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Supervision, Inspection & Testing Center of Agricultural Products Quality, Ministry of Agriculture and Rural Affairs, Beijing 100083, China.
Int J Mol Sci. 2021 May 29;22(11):5849. doi: 10.3390/ijms22115849.
In recent years, much progress has been made in elucidating the functional roles of plant glycine-rich RNA-binding proteins (GR-RBPs) during development and stress responses. Canonical GR-RBPs contain an RNA recognition motif (RRM) or a cold-shock domain (CSD) at the N-terminus and a glycine-rich domain at the C-terminus, which have been associated with several different RNA processes, such as alternative splicing, mRNA export and RNA editing. However, many aspects of GR-RBP function, the targeting of their RNAs, interacting proteins and the consequences of the RNA target process are not well understood. Here, we discuss recent findings in the field, newly defined roles for GR-RBPs and the actions of GR-RBPs on target RNA metabolism.
近年来，在阐明植物甘氨酸丰富的 RNA 结合蛋白（GR-RBPs）在发育和应激反应中的功能作用方面取得了很大进展。典型的 GR-RBPs 在 N 端含有 RNA 识别基序（RRM）或冷休克结构域（CSD），在 C 端含有甘氨酸丰富的结构域，与几种不同的 RNA 过程有关，如选择性剪接、mRNA 输出和 RNA 编辑。然而，GR-RBP 功能的许多方面、其 RNA 的靶向、相互作用的蛋白质以及 RNA 靶代谢过程的后果尚不清楚。在这里，我们讨论了该领域的最新发现，重新定义了 GR-RBPs 的作用以及 GR-RBPs 对靶 RNA 代谢的作用。
