Nishihama Yukiko, Nakayama Shoji F, Isobe Tomohiko, Jung Chau-Ren, Iwai-Shimada Miyuki, Kobayashi Yayoi, Michikawa Takehiro, Sekiyama Makiko, Taniguchi Yu, Yamazaki Shin
Japan Environment and Children's Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan.
Department of Public Health, College of Public Health, China Medical University, Taichung City 406040, Taiwan.
Int J Environ Res Public Health. 2021 May 31;18(11):5929. doi: 10.3390/ijerph18115929.
Organophosphate pesticides (OPPs) exhibit neurodevelopmental toxicity. To evaluate the effect of prenatal exposure to OPPs in the Japan Environment and Children's Study, a nationally representative birth cohort study, 4575 maternal urine samples were analysed for six OPP metabolites, i.e., dialkylphosphates (DAPs). This study aimed to investigate predictors of urinary DAPs using machine learning approaches and to assess the cumulative risk based on relative potency factors among Japanese pregnant women. The median creatinine-normalised urinary concentrations (interquartile ranges) of dimethylphosphate, dimethylthiophosphate and diethylphosphate, which had a detection rate of 50% or higher, were 3.53 (1.91-6.78), 4.09 (1.66-10.8) and 3.28 (1.88-5.98) µg/g-creatinine, respectively. Possible predictors of urinary DAP concentrations were the month of urine sampling, consumption of apple and maternal body mass index. When fenitrothion was used as an index chemical for cumulative risk assessment, 0.36% of participants exceeded the lower 95% confidence limit of the benchmark dose.
有机磷酸酯类农药（OPPs）具有神经发育毒性。在日本环境与儿童研究（一项具有全国代表性的出生队列研究）中，为评估孕期接触OPPs的影响，对4575份孕妇尿液样本进行了六种OPPs代谢物（即二烷基磷酸酯，DAPs）的分析。本研究旨在使用机器学习方法探究尿中DAPs的预测因素，并基于相对效力因子评估日本孕妇的累积风险。磷酸二甲酯、甲基硫代磷酸酯和磷酸二乙酯的肌酐标准化尿浓度中位数（四分位间距）分别为3.53（l.91 - 6.78）、4.09（1.66 - 10.8）和3.28（1.88 - 5.98）μg/g肌酐，其检出率达50%或更高。尿中DAP浓度的可能预测因素为尿液采样月份、苹果摄入量和孕妇体重指数。当以杀螟硫磷作为累积风险评估的指示化学品时，036%的参与者超过了基准剂量的95%置信下限。
